RET, ROS1 and ALK fusions in lung cancer.

Nature Medicine
Kengo TakeuchiYuichi Ishikawa

Abstract

Through an integrated molecular- and histopathology-based screening system, we performed a screening for fusions of anaplastic lymphoma kinase (ALK) and c-ros oncogene 1, receptor tyrosine kinase (ROS1) in 1,529 lung cancers and identified 44 ALK-fusion-positive and 13 ROS1-fusion-positive adenocarcinomas, including for unidentified fusion partners for ROS1. In addition, we discovered previously unidentified kinase fusions that may be promising for molecular-targeted therapy, kinesin family member 5B (KIF5B)-ret proto-oncogene (RET) and coiled-coil domain containing 6 (CCDC6)-RET, in 14 adenocarcinomas. A multivariate analysis of 1,116 adenocarcinomas containing these 71 kinase-fusion-positive adenocarcinomas identified four independent factors that are indicators of poor prognosis: age ≥ 50 years, male sex, high pathological stage and negative kinase-fusion status.

References

Jan 2, 2008·Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer·Kentaro InamuraYuichi Ishikawa
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kengo TakeuchiHiroyuki Mano
Apr 23, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kengo TakeuchiHiroyuki Mano
Sep 23, 2010·Biologics : Targets & Therapy·Jaclyn FlaniganScott Gettinger
Mar 25, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kengo TakeuchiYuichi Ishikawa

❮ Previous
Next ❯

Citations

Oct 31, 2013·Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz·R Buettner, C Heydt
Jul 25, 2012·Virchows Archiv : an International Journal of Pathology·Erik ThunnissenGiulio Rossi
Jun 19, 2013·Current Oncology Reports·Shirish M Gadgeel
Jan 30, 2013·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·E CondeF López-Ríos
Jul 31, 2013·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Nicla BorrelliGabriella Fontanini
Sep 28, 2013·Nature Genetics·UNKNOWN Cancer Genome Atlas Research NetworkJoshua M Stuart
Oct 18, 2013·Nature Reviews. Cancer·Alice T ShawJeffrey A Engelman
Apr 12, 2013·Genetic Testing and Molecular Biomarkers·Yao-Shan Fan
Sep 26, 2012·Annals of Oncology : Official Journal of the European Society for Medical Oncology·S Zimmermann, S Peters
Jan 2, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·J X ZhouJ He
Mar 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·W CaiG Schmid-Bindert
Jun 22, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·H R KimB C Cho
Sep 15, 2012·Open Biology·Marie-Liesse Asselin-Labat, Caitlin E Filby
Sep 15, 2012·Genome Research·Jeong-Sun SeoYoung Tae Kim
Nov 1, 2013·Science Translational Medicine·UNKNOWN Clinical Lung Cancer Genome Project (CLCGP), UNKNOWN Network Genomic Medicine (NGM)
Aug 25, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kurtis D DaviesRobert C Doebele
Mar 22, 2013·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Kadoaki OhashiWilliam Pao
Sep 26, 2013·BMC Cancer·Stefania StaibanoAngela Celetti
Feb 13, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Geoffrey R OxnardPasi A Jänne
Feb 19, 2013·PloS One·Yasuhito AraiTatsuhiro Shibata
Sep 17, 2013·PloS One·Laura W DillonYuh-Hwa Wang
Nov 12, 2013·Chinese Journal of Cancer·Brittany C Parker, Wei Zhang
Dec 1, 2012·Archives of Pathology & Laboratory Medicine·Philip T Cagle, Timothy Craig Allen
Sep 3, 2013·Archives of Pathology & Laboratory Medicine·Philip T CagleRandall J Olsen
Aug 2, 2014·PloS One·Joaquim BellmuntJonathan E Rosenberg
Nov 11, 2014·Nature Medicine·Zongli ZhengLong Phi Le

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nature Medicine
Takashi KohnoTatsuhiro Shibata
Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Kristin BergethonA John Iafrate
Journal of Thoracic Oncology : Official Publication of the International Association for the Study of Lung Cancer
Daisuke MatsubaraToshiro Niki
© 2022 Meta ULC. All rights reserved