PMID: 9163786May 1, 1997Paper

Retardation of pancreatic regeneration after partial pancreatectomy in a strain of rats without CCK-A receptor gene expression

Pancreas
K MiyasakaA Funakoshi

Abstract

This study extends a recent observation that Otsuka Long-Evans Tokushima Fatty (OLETF) rats show no expression of the cholecystokinin (CCK)-A receptor gene in the pancreas because of a genetic abnormality. We compared the changes in pancreatic regeneration in terms of wet weight and protein and DNA contents after partial pancreatectomy (30% resection) in OLETF and control (Long-Evans Tokushima Otsuka: LETO) rats and examined whether the CCK-B receptor has a role in pancreatic regeneration after pancreatectomy. The pancreatic wet weight increased significantly with age in both OLETF and LETO rats regardless of surgical procedure, but the increase with respect to time was significantly less in OLETF than in LETO rats. The protein and DNA concentrations in the pancreas (mg/g wet tissue) were comparable for both strains after sham operation. However, they were significantly lower than pancreatectomy in OLETF rats compared to those after sham operation, whereas they were comparable in LETO rats regardless of surgical procedure. The ratio of protein content/DNA content (cell size) was significantly lower in OLETF than LETO rats under all conditions. CCK-B receptor gene expression was not enhanced after pancreatectomy. In conclusion, ...Continue Reading

Citations

Dec 1, 2006·Nutrition Research Reviews·P GuilloteauR Zabielski
Mar 31, 2012·American Journal of Physiology. Gastrointestinal and Liver Physiology·Lili GuoJohn A Williams
Nov 10, 2016·Acta Cirúrgica Brasileira·José Marcus Raso EulálioAlberto Schanaider
Jul 4, 2006·Physiological Reviews·Marlène DufresneDaniel Fourmy
Sep 6, 2007·Ultrastructural Pathology·E C SeretisI E Voloudakis-Baltatzis
Mar 16, 2005·Clinical Science·Zoë D Burke, David Tosh
Nov 5, 2002·Diabetes Research and Clinical Practice·Makarand V Risbud, Ramesh R Bhonde

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