PMID: 3756500Aug 27, 1986Paper

Retardation of resynthesis of GABA-transaminase in some brain regions of amygdala-kindled rats

Brain Research
S Itagaki, H Kimura

Abstract

The activities of GABA-transaminase (GABA-T) were examined in several brain regions of amygdala-kindled rats, pretreated either with or without gabaculine, an irreversible GABA-T inhibitor. Histochemical and biochemical studies demonstrated that GABA-T activities decreased significantly in some brain regions 16 h after the gabaculine treatment. In contrast, no such alteration was detected in kindled animals after a 48-h survival period either with or without the pharmacological manipulation. The present results suggest that kindling causes retardation of GABA-T resynthesis in neurons, since the GABA-T activities detected 16 h after the drug treatment are due to newly synthetized enzyme in presumptive GABA neurons but not glial cells.

References

Jan 1, 1975·International Review of Neurobiology·B S Meldrum
Jun 20, 1977·Biochemical and Biophysical Research Communications·R R Rando, F W Bangerter
Jan 8, 1985·The Journal of Comparative Neurology·T NagaiE G McGeer
Mar 1, 1972·Electroencephalography and Clinical Neurophysiology·R J Racine
Nov 1, 1969·Experimental Neurology·G V GoddardC K Leech
Aug 11, 1972·Brain Research·D R CurtisR M MacLachlan
Dec 11, 1982·Lancet·L Spero
Aug 1, 1983·Life Sciences·H B NiznikW M Burnham
Aug 1, 1983·The Journal of Comparative Neurology·T NagaiE G McGeer
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J O McNamaraV Patrone
Mar 1, 1980·Neuroscience Letters·S R VincentE G McGeer
Apr 1, 1980·Epilepsia·M S Myslobodsky, E S Valenstein
Jan 1, 1980·Canadian Journal of Physiology and Pharmacology·G Le Gal La Salle
Apr 1, 1935·Postgraduate Medical Journal·W R Brain

❮ Previous
Next ❯

Citations

Sep 1, 1986·The Japanese Journal of Psychiatry and Neurology·S ItagakiH Kimura

❮ Previous
Next ❯

Related Concepts

Related Feeds

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Amygdala: Sensory Processes

Amygdalae, nuclei clusters located in the temporal lobe of the brain, play a role in memory, emotional responses, and decision-making. Here is the latest research on sensory processes in the amygdala.