PMID: 3754480May 1, 1986Paper

Retarded growth of the suprachiasmatic nucleus and pineal body in dw and lit dwarf mice

Brain Research
T NoguchiI Satoh

Abstract

The suprachiasmatic nucleus (SCN) and the pineal body in 3 types of inherited hormone-deficient mice, the dw, lit and hyt mice were examined by morphological, morphometric and biochemical techniques. In the dw and lit mice the SCN was underdeveloped. In the ventral part of the SCN, where most of the retinal fibers appeared to terminate, both cell number and cell size were decreased, although the size of the SCN was unaltered. In addition, the pineal bodies of both mice were morphologically underdeveloped and showed low levels of N-acetyltransferase activity. In contrast, the hyt SCN was comparable to the normal controls in every respect. The hyt pineal was well developed and showed levels of enzyme activity comparable to the controls. However, in all the deficient mice, the optic nerve appeared to be normal in morphological and biochemical studies. These results suggest that the underdevelopment of the pineal body, the reduced levels of spontaneous locomotion and the indistinct diurnal periodicity of the dw and lit mice might be related to the retarded neuronal growth of the SCN, and that growth hormone likely is indispensable for the development of the SCN.

References

Jan 1, 1977·Psychoneuroendocrinology·L P MorinI Zucker
Mar 24, 1977·Cell and Tissue Research·N J LennR Y Moore
Jul 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·T Deguchi
Nov 25, 1975·The Journal of Comparative Neurology·V S Caviness
Jul 1, 1985·Experimental Neurology·T Noguchi, T Sugisaki
Jun 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·F K Stephan, I Zucker
Jan 1, 1972·Zeitschrift für Zellforschung und mikroskopische Anatomie·A E HendricksonW M Cowan
Nov 1, 1972·Analytical Biochemistry·T Deguchi, J Axelrod
Oct 1, 1983·Brain Research·T NoguchiK Shimai
Mar 1, 1984·Journal of Neurochemistry·T Noguchi, T Sugisaki
Dec 1, 1982·Journal of Neurochemistry·T NoguchiY Tsukada
Jan 1, 1984·Neurochemical Pathology·T NoguchiY Tsukada
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·J L Fuchs, R Y Moore
Apr 3, 1981·Science·W J BeamerJ L Southard
Sep 15, 1929·Proceedings of the National Academy of Sciences of the United States of America·G D Snell

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Citations

Jun 1, 1991·Physiology & Behavior·W J Schwartz, P Zimmerman
Oct 21, 1991·Brain Research. Developmental Brain Research·S PonsI Torres-Aleman
Jan 1, 1988·Progress in Neurobiology·T Noguchi
Oct 1, 1992·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·T SugisakiT Noguchi
Jan 1, 1991·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·T Noguchi
Nov 28, 1994·Brain Research·T SugisakiT Noguchi

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