PMID: 9165299Jan 1, 1997Paper

Retarding effect of dietary restriction on the accumulation of 8-hydroxy-2'-deoxyguanosine in organs of Fischer 344 rats during aging

Free Radical Biology & Medicine
T KanekoM Matsuo

Abstract

An age-related accumulation in rats of 8-hydroxy-2'-deoxyguanosine (8-OHdG), a marker of oxidative DNA damage, and the effect of dietary restriction on the accumulation of 8-OHdG were examined. The 8-OHdG concentrations of nuclear DNA in organs of ad libitum fed rats were similar in young and middle age, but increased significantly in kidney at 24 months of age, in heart and liver at 27 months of age, and in brain at 30 months of age. The 8-OHdG concentration in dietary-restricted rats showed no changes in any organ up to 30 months of age and then was increased at 33 months of age. Dietary restriction retarded the onset of the age-related increase in 8-OHdG concentration, although it did not reduce the concentration in young and middle age. These results suggest that the effect of dietary restriction on the extension of life-span in rats might be related to a reduction in oxidative damage.

References

Aug 28, 1992·Science·E R Stadtman
Jan 1, 1992·Free Radical Biology & Medicine·M H ChungB P Yu
Dec 1, 1990·Aging : Clinical and Experimental Research·D W Lee, B P Yu
Sep 1, 1990·Carcinogenesis·R A Floyd
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·C G FragaB N Ames
Jan 1, 1989·Free Radical Research Communications·B N Ames
Jun 1, 1989·Mechanisms of Ageing and Development·S Laganiere, B P Yu
Jul 1, 1986·Analytical Biochemistry·M Dizdaroglu, D S Bergtold
Sep 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C RichterB N Ames
Jun 30, 1987·Biochemical and Biophysical Research Communications·S Laganiere, B P Yu
Jan 1, 1985·Mechanisms of Ageing and Development·N NoyA Gafni
Nov 1, 1985·Journal of Gerontology·H MaedaB P Yu
Jan 1, 1981·Journal of Cancer Research and Clinical Oncology·R Müller, M F Rajewsky
Jan 1, 1982·Journal of the American College of Nutrition·D Harman
Oct 20, 1994·Mechanisms of Ageing and Development·R S SohalH Lal
Oct 29, 2003·Antioxidants & Redox Signaling·Denham Harman

❮ Previous
Next ❯

Citations

Sep 8, 2006·Biogerontology·Keiko UnnoMinoru Hoshino
May 17, 2005·Mechanisms of Ageing and Development·B J Merry
Jun 16, 2000·Mechanisms of Ageing and Development·J A GreenbergC N Boozer
Mar 10, 2001·Mechanisms of Ageing and Development·S TaharaT Kaneko
Oct 24, 2001·Experimental Gerontology·K Hirokawa, S Goto
Feb 16, 2000·Progress in Retinal and Eye Research·J CaiD P Jones
Feb 3, 2009·Journal of Toxicology and Environmental Health. Part a·Mohammed AzabKarem Alzoubi
Apr 24, 2002·Antioxidants & Redox Signaling·Zsolt RadakSataro Goto
May 9, 2006·Antioxidants & Redox Signaling·Arnold Y SeoChristiaan Leeuwenburgh
Jun 29, 2002·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·R WeindruchS R Spindler
Oct 19, 2007·Nucleic Acids Research·Ahmad R HeydariArlan Richardson
Jan 5, 2010·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Toru Sasaki
Feb 14, 2013·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Husam KhraiweshJosé A González-Reyes
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·M L HamiltonA Richardson
Jun 8, 2013·Free Radical Biology & Medicine·Michael E WalshHolly Van Remmen
Sep 11, 2001·Biochemical and Biophysical Research Communications·L J Roberts, J F Reckelhoff
Mar 28, 2013·Oxidative Medicine and Cellular Longevity·Aleksei V ErmakovNatalya N Veiko
Feb 23, 2012·Ageing Research Reviews·Alexey A MoskalevVadim E Fraifeld
Mar 7, 2013·Evolution; International Journal of Organic Evolution·Catharine R ArcherJohn Hunt
Apr 5, 2003·Brain Research·Lisa GiovannelliLuigi Pulvirenti
Jul 14, 2001·Redox Report : Communications in Free Radical Research·Z RadakT Kanel
Dec 27, 2011·Redox Report : Communications in Free Radical Research·Alicia J Kowaltowski
Apr 27, 2007·Annals of the New York Academy of Sciences·Sataro GotoRamesh Sharma
Jul 25, 2013·Geriatrics & Gerontology International·Toru SasakiShuji Kojima
Oct 20, 2001·The Tohoku Journal of Experimental Medicine·Y WakoK Suzuki
Oct 9, 2008·Acta Biologica Hungarica·Gabrielle de Souza RochaR Santos
Oct 25, 2011·Molecular Aspects of Medicine·Zsolt RadakErika Koltai
Dec 1, 2009·Clinics in Geriatric Medicine·Emanuele MarzettiChristiaan Leeuwenburgh
Jul 12, 2005·Experimental Gerontology·Reiko NagasakaHideki Ushio

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Free Radical Biology & Medicine
M H ChungB P Yu
Proceedings of the National Academy of Sciences of the United States of America
C G FragaB N Ames
Proceedings of the National Academy of Sciences of the United States of America
M L HamiltonA Richardson
© 2021 Meta ULC. All rights reserved