PMID: 11604321Oct 18, 2001Paper

Retargeting gene delivery using surface-engineered retroviral vector particles

Current Opinion in Biotechnology
D LavilletteF L Cosset

Abstract

Retroviral vectors with the capacity to deliver transgenes to specific tissues are expected to be of great value for various gene transfer applications in vivo. Initial attempts to modify vector host-range by the insertion of ligands on their surface glycoproteins have frequently failed, essentially owing to the impairment of the fusogenicity of the vector particles bound to the targeted cell-surface molecules. Several strategies aimed to recover the fusogenic activity of surface-engineered vector particles have recently been explored and have given rise to novel concepts in the field.

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Citations

Jan 24, 2004·Journal of Hepatology·Antonia Follenzi, Sanjeev Gupta
Feb 22, 2003·Biochimie·Didier Nègre, François-Loïc Cosset
Dec 3, 2002·Current Opinion in Biotechnology·David Avram Sanders
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Sep 9, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jiwon ChoiEdward M Callaway
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Jul 26, 2006·Proceedings of the National Academy of Sciences of the United States of America·Lili YangPin Wang
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