Retention and mortality on antiretroviral therapy in sub-Saharan Africa: collaborative analyses of HIV treatment programmes

Journal of the International AIDS Society
Andreas D HaasAfrican regions of the International epidemiologic Databases to Evaluate AIDS (IeDEA)

Abstract

By 2020, 90% of all people diagnosed with HIV should receive long-term combination antiretroviral therapy (ART). In sub-Saharan Africa, this target is threatened by loss to follow-up in ART programmes. The proportion of people retained on ART long-term cannot be easily determined, because individuals classified as lost to follow-up, may have self-transferred to another HIV treatment programme, or may have died. We describe retention on ART in sub-Saharan Africa, first based on observed data as recorded in the clinic databases, and second adjusted for undocumented deaths and self-transfers. We analysed data from HIV-infected adults and children initiating ART between 2009 and 2014 at a sub-Saharan African HIV treatment programme participating in the International epidemiology Databases to Evaluate AIDS (IeDEA). We used the Kaplan-Meier method to calculate the cumulative incidence of retention on ART and the Aalen-Johansen method to calculate the cumulative incidences of death, loss to follow-up, and stopping ART. We used inverse probability weighting to adjust clinic data for undocumented mortality and self-transfer, based on estimates from a recent systematic review and meta-analysis. We included 505,634 patients: 12,848 (2.5%)...Continue Reading

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Citations

May 3, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Martin MudduJeremy I Schwartz
Jul 20, 2019·Journal of the International AIDS Society·Ade O FakoyaPeter Sands
Nov 5, 2019·AIDS Patient Care and STDs·Karl W Le RouxMary Jane Rotheram-Borus
Nov 13, 2019·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Adam W BartlettUNKNOWN TREAT Asia Pediatric HIV Observational Database of IeDEA Asia-Pacific
Apr 17, 2020·Journal of the International AIDS Society·UNKNOWN Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) Global Cohort Collaboration
Jul 10, 2018·Pathogens and Disease·Anna BershteynUNKNOWN Institute for Disease Modeling
Jun 27, 2019·Health Care for Women International·Sara ChandyMaria L Ekstrand
May 20, 2020·Current HIV/AIDS Reports·Matthew A SpinelliMonica Gandhi
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Dec 4, 2020·The Lancet. HIV·Mark DybulUNKNOWN Sunnylands 2019 Working Group
Sep 6, 2020·American Journal of Epidemiology·Fiona VanobberghenOn Behalf Of The Kiularco Study Group
Feb 2, 2021·American Journal of Epidemiology·Fiona VanobberghenTracy R Glass On Behalf Of The Kiularco Study Group
Aug 14, 2020·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Marco FloridiaMaria Cristina Marazzi
Apr 4, 2021·International Journal of Environmental Research and Public Health·Massimo LeoneMaria Cristina Marazzi
Jul 7, 2020·Lancet·Matthew M KavanaghCharles B Holmes
May 6, 2021·Current HIV/AIDS Reports·Aaloke ModyElvin H Geng
May 23, 2021·Journal of the International AIDS Society·Thierry TiendrebeogoUNKNOWN IeDEA West Africa Collaboration

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