PMID: 11916508Mar 28, 2002Paper

Retention of antigen on follicular dendritic cells and B lymphocytes through complement-mediated multivalent ligand-receptor interactions: theory and application to HIV treatment

Mathematical Biosciences
William S HlavacekC Wofsy

Abstract

In HIV-infected patients, large quantities of HIV are associated with follicular dendritic cells (FDCs) in lymphoid tissue. During antiretroviral therapy, most of this virus disappears after six months of treatment, suggesting that FDC-associated virus has little influence on the eventual outcome of long-term therapy. However, a recent theoretical study using a stochastic model for the interaction of HIV with FDCs indicated that some virus may be retained on FDCs for years, where it can potentially reignite infection if treatment is interrupted. In that study, an approximate expression was used to estimate the time an individual virion remains on FDCs during therapy. Here, we determine the conditions under which this approximation is valid, and we develop expressions for the time a virion spends in any bound state and for the effect of rebinding on retention. We find that rebinding, which is influenced by diffusion, may play a major role in retention of HIV on FDCs. We also consider the possibility that HIV is retained on B cells during therapy, which like FDCs also interact with HIV. We find that virus associated with B cells is unlikely to persist during therapy.

References

Oct 1, 1990·Immunological Reviews·J G TewA K Szakal
Jan 1, 1980·Immunological Reviews·T E MandelJ G Tew
Jun 1, 1994·Journal of Virological Methods·M GentileH R Gelderblom
Jan 1, 1997·Annual Review of Immunology·H StoiberM P Dierich
Apr 1, 1997·Immunological Reviews·G F BurtonA K Szakal
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·J K WongD D Richman
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·Z Q ZhangA T Haase
Apr 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·Z Q ZhangA T Haase
May 8, 1999·Biophysical Journal·W S HlavacekR G Posner
May 26, 1999·The New England Journal of Medicine·L ZhangD D Ho
Sep 29, 1999·Proceedings of the National Academy of Sciences of the United States of America·T W Chun, A S Fauci
Nov 30, 1999·JAMA : the Journal of the American Medical Association·G DornadulaR J Pomerantz
Dec 28, 1999·Proceedings of the National Academy of Sciences of the United States of America·W S HlavacekA S Perelson
Feb 12, 2000·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·K C Holmes
Sep 20, 2000·Proceedings of the National Academy of Sciences of the United States of America·W S HlavacekA S Perelson
Feb 24, 2001·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·W S HlavacekA S Perelson

❮ Previous
Next ❯

Citations

Feb 12, 2009·Expert Reviews in Molecular Medicine·Mary-Catherine BowmanDavid M Margolis
Jun 3, 2004·Nature Reviews. Immunology·Byron GoldsteinWilliam S Hlavacek
May 10, 2013·Journal of Virology·Jingshan Zhang, Alan S Perelson
Sep 9, 2010·PLoS Computational Biology·Rob J De BoerAlan S Perelson
Feb 16, 2016·Trends in Microbiology·Kirston BartonSarah Palmer
Jun 11, 2004·Biophysical Journal·Thomas J English, Daniel A Hammer
Oct 3, 2012·Advanced Drug Delivery Reviews·Shi XuSarah F Hamm-Alvarez
Mar 9, 2005·Immunology Letters·Zoltán BánkiManfred P Dierich
Jun 29, 2007·Biotechnology and Bioengineering·Philippe-Alexandre GilbertAlain Garnier
Aug 10, 2011·Current Opinion in HIV and AIDS·Georg HuberHeribert Stoiber
May 17, 2019·The Journal of Chemical Physics·Nicholas B Tito
Jan 18, 2020·Journal of Physics. Condensed Matter : an Institute of Physics Journal·Tine Curk, Nicholas B Tito
Oct 16, 2018·Frontiers in Immunology·Shinjini ChakrabortyMarkus Huber-Lang
Aug 25, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ambarish NagByron Goldstein
Dec 3, 2020·Advanced Drug Delivery Reviews·Laura WoytheLorenzo Albertazzi
Apr 19, 2016·Bioconjugate Chemistry·Evan M PeckBradley D Smith

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Related Papers

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences
William S HlavacekA S Perelson
Proceedings of the National Academy of Sciences of the United States of America
William S HlavacekA S Perelson
Proceedings of the National Academy of Sciences of the United States of America
William S HlavacekA S Perelson
Seminars in Immunology
Gregory F BurtonSuzanne Gartner
© 2022 Meta ULC. All rights reserved