PMID: 8994398Dec 1, 1996Paper

Retention of asbestos fibres in lungs of workers with asbestosis, asbestosis and lung cancer, and mesothelioma in Asbestos township

Occupational and Environmental Medicine
André DufresneG Perrault

Abstract

To conduct a mineralogical study on the particles retained in the necropsied lungs of a homogenous group of asbestos miners and millers from Asbestos township (and a local reference population) and to consider the hypothesis that there is a difference in size between fibres retained in the lungs of patients with asbestosis with and without lung cancer. Samples of lung tissue were obtained from 38 patients with asbestosis without lung cancer, 25 with asbestosis and lung cancer, and 12 with mesothelioma, from necropsied Quebec chrysotile miners and millers from Asbestos township. Fibre concentrations in the lungs of these patients were compared with those in tissue from necropsies carried out on a local reference population: men who had died of either accidental death or acute myocardial infarction between 1990 and 1992. 23 were born before 1940 and 26 after 1940. Geometric mean (GM) concentrations were higher in cases than in the controls for chrysotile fibres 5 to 10 microns long in patients with asbestosis with or without lung cancer; for tremolite fibres 5 to 10 microns long in all patients; for crocidolite, talc, or anthophyllite fibres 5 to 10 microns long in patients with mesothelioma; for chrysotile and tremolite fibres >...Continue Reading

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Citations

Feb 5, 2000·Occupational and Environmental Medicine·A DufresneR Bégin
Mar 20, 2001·American Journal of Respiratory and Critical Care Medicine·R Bégin, J W Christman
Mar 17, 2010·Archivos de bronconeumología·María Isabel Velasco-GarcíaJaume Ferrer
Mar 28, 2013·American Journal of Industrial Medicine·Georges AdibAndré Dufresne
Dec 14, 2011·Journal of Veterinary Internal Medicine·Wallace B Morrison
Mar 23, 1999·American Journal of Industrial Medicine·M M Finkelstein, A Dufresne
Oct 27, 2018·BMJ Global Health·Churnrurtai KanchanachitraTipicha Posayanonda
Jul 1, 1998·Clinics in Chest Medicine·S L Nishimura, V C Broaddus

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