Retention of Gadolinium-Based Contrast Agents in Multiple Sclerosis: Retrospective Analysis of an 18-Year Longitudinal Study.

AJNR. American Journal of Neuroradiology
Y ForslinT Granberg

Abstract

Gadolinium-based contrast agents have been associated with lasting high T1-weighted signal intensity in the dentate nucleus and globus pallidus, with histopathologically confirmed gadolinium retention. We aimed to longitudinally investigate the relationship of multiple gadolinium-based contrast agent administrations to the Signal Intensity Index in the dentate nucleus and globus pallidus and any associations with cognitive function in multiple sclerosis. The Signal Intensity Index in the dentate nucleus and globus pallidus was retrospectively evaluated on T1-weighted MR imaging in an 18-year longitudinal cohort study of 23 patients with MS receiving multiple gadolinium-based contrast agent administrations and 23 healthy age- and sex-matched controls. Participants also underwent comprehensive neuropsychological testing. Patients with MS had a higher Signal Intensity Index in the dentate nucleus (P < .001), but not in the globus pallidus (P = .19), compared with non-gadolinium-based contrast agent-exposed healthy controls by an unpaired t test. Increasing numbers of gadolinium-based contrast agent administrations were associated with an increased Signal Intensity Index in the dentate nucleus (β = 0.45, P < .001) and globus pallid...Continue Reading

References

Mar 1, 1983·Annals of Neurology·C M PoserW W Tourtellotte
Jun 6, 2003·Applied Neuropsychology·Alexander I TrösterJulie A Fields
Nov 13, 2008·Investigative Radiology·Thomas FrenzelHanns-Joachim Weinmann
Sep 12, 2009·Radiologic Clinics of North America·Jean-Marc IdéeClaire Corot
Dec 14, 2011·Archives of Neurology·Massimo FilippiGiancarlo Comi
Mar 21, 2012·NeuroImage·Martin ReuterBruce Fischl
Mar 24, 2012·Lancet Neurology·Massimo FilippiUNKNOWN Attendees of the Correlation between Pathological MRI findings in MS workshop
Aug 7, 2012·European Radiology·Henrik S ThomsenUNKNOWN ESUR Contrast Medium Safety Committee
Dec 10, 2013·The Cerebellum·Peter MariënWolfram Ziegler
Sep 27, 2014·Critical Reviews in Toxicology·Jean-Marc IdéeClaire Corot
Feb 11, 2015·Lancet Neurology·Maria A RoccaUNKNOWN MAGNIMS Study Group
Mar 6, 2015·Radiology·Robert J McDonaldLaurence J Eckel
Jan 27, 2016·Advances in Therapy·Jessica LohrkeHubertus Pietsch
Mar 10, 2016·Investigative Radiology·Donna R RobertsW Clay Davis
Jun 22, 2016·Journal of the American College of Radiology : JACR·Hans-Klaus Goischke
Jul 6, 2016·JAMA : the Journal of the American Medical Association·Blayne WelkAndrea Lum
Jul 15, 2016·Multiple Sclerosis : Clinical and Laboratory Research·Emilia SbardellaPatrizia Pantano

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Citations

Jan 26, 2018·Magnetic Resonance in Medical Sciences : MRMS : an Official Journal of Japan Society of Magnetic Resonance in Medicine·Toshiaki Taoka, Shinji Naganawa
Mar 11, 2018·Clinical Neuroradiology·Richard PullicinoKumar Das
Oct 19, 2017·Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences·Joel GarciaAngelique Y Louie
Nov 11, 2018·European Radiology·Carlo C QuattrocchiUNKNOWN GREC, European Gadolinium Retention Evaluation Consortium and the ESNR, European Society of Neuroradiology
Apr 10, 2019·Der Radiologe·P RaczeckG Schneider
Aug 6, 2018·Pediatric Radiology·Michael N Rozenfeld, Daniel J Podberesky
Apr 23, 2020·Neuroradiology·Carlo A MallioCarlo C Quattrocchi
Mar 31, 2021·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Kerem Ozturk, David Nascene
Apr 20, 2021·Clinical Liver Disease·Robert M MarksJames T Lee
May 25, 2020·Seminars in Ultrasound, CT, and MR·Colleen M CostelloeJohn E Madewell
Aug 8, 2021·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Chiara FurlanEliana Gianolio
Nov 5, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Isabelle KühnUwe Walter

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