PMID: 8591793Nov 1, 1995Paper

Retention of particles inhaled in boli with and without induced bronchoconstriction

Experimental Lung Research
G ScheuchP Camner

Abstract

Large lung retentions (up to 50%) of particles < or = 4 microns inhaled with a bolus technique at a penetration depth less than dead space have been reported to occur after 24 h. This retention may be due to retarded clearance of particles deposited in the airways of the tracheobronchial tract; an alternative explanation could be that particles are deposited in the alveolar region. The purpose of the present study was to confirm the occurrence of retained fractions and to study the influence of a cholinergic drug, which is assumed to give a more central particle deposition, on these retentions in human lungs after shallow aerosol bolus inhalation. Twelve healthy subjects inhaled, with a bolus technique, monodisperse Teflon particles (2.4 microns geometric diameter, 3.5 microns aerodynamic diameter), labeled with 111In. The volumetric lung depth of the inspired bolus was around 60 mL and flow rate was about 300 mL/s. Six subjects inhaled the test particles after a provocation with a cholinergic aerosol, which induced a threefold increase in airway resistance. The other six subjects inhaled a cholinergic aerosol after inhalation of the test particles or inhaled no cholinergic aerosol at all. Radioactivity in the body was measured...Continue Reading

References

Jul 1, 1978·Archives of Environmental Health·P Camner, K Philipson
Dec 1, 1991·Journal of Applied Physiology·M SvartengrenP Camner
Jul 1, 1989·Experimental Lung Research·M SvartengrenP Camner
Oct 1, 1974·Archives of Environmental Health·P CammerK Philipson
Jan 1, 1984·Experimental Lung Research·M SvartengrenP Camner

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Citations

Sep 30, 2000·Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine·M RobinsonP T Bye
Dec 6, 2001·American Journal of Respiratory and Critical Care Medicine·N E AlexisW D Bennett
Apr 29, 1998·Experimental Lung Research·K SvartengrenP Camner
Nov 14, 1997·Experimental Lung Research·R FalkP Camner
Nov 14, 1997·Experimental Lung Research·P CamnerM Svartengren
Jan 14, 1999·Journal of Applied Physiology·W D BennettW Stahlhofen

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