Mar 9, 2013

Retention of tocilizumab and anti-tumour necrosis factor drugs in the treatment of rheumatoid arthritis

Scandinavian Journal of Rheumatology
Y HishitaniAtsushi Kumanogoh

Abstract

The retention of the anti-rheumatic agent tocilizumab (TCZ) has not been well documented in patients with rheumatoid arthritis (RA). We conducted an observational study to compare the retention of TCZ and anti-tumour necrosis factor (TNF) drugs in the treatment of patients with RA. We reviewed continuation rates and causes of discontinuation of biological agents (biologics) by assessing medical records of patients with RA who were administered biologics at our institute from September 1999 to April 2012, using the Osaka University Biologics for Rheumatic Diseases (BiRD) registry. A total of 401 patients were included. TCZ, infliximab (IFX), etanercept (ETN), and adalimumab (ADA) were administered to 97, 103, 143, and 58 patients, respectively. There were some differences between the baseline characteristics of the groups. The median duration (range) of TCZ, IFX, ETN, and ADA administration was 2.5 (0.1-12.6), 1.9 (0.0-7.7), 2.9 (0.0-11.3), and 1.3 (0.0-3.4) years, respectively. Continuation rates for TCZ and ETN were significantly higher than those for IFX and ADA. Multivariate analyses showed that discontinuation due to lack or loss of efficacy was significantly less common in the TCZ group than in the other groups. Discontinu...Continue Reading

  • References28
  • Citations16

References

  • References28
  • Citations16

Citations

Mentioned in this Paper

Monoclonal Antibodies
Necrosis
Tumor Necrosis Factor-alpha
Humira
Antirheumatic Agents
Biological Products
Kaplan-Meier Estimate
Tumor Lysis Syndrome
Severity of Illness Index
Incidence Studies

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