Retention Rate and Efficacy of the Biosimilar CT-P13 Versus Reference Infliximab in Patients with Ankylosing Spondylitis: A Propensity Score-Matched Analysis from the Korean College of Rheumatology Biologics Registry.

BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
Hyoun-Ah KimKichul Shin

Abstract

Long-term, real-world data are required to support the use of CT-P13 in chronic conditions such as ankylosing spondylitis. However, real-world evidence may be influenced by selection bias, which can confound outcomes. The aim of the current analysis was to confirm the long-term comparability of CT-P13 and reference infliximab treatment in patients with ankylosing spondylitis, using propensity score matching to adjust for baseline differences between groups. A propensity score-matching analysis was conducted on data from patients with ankylosing spondylitis in the Korean College of Rheumatology Biologics registry who received CT-P13 or reference infliximab. Drug retention, reasons for biologic therapy changes or discontinuation, and efficacy parameters were analyzed overall and by treatment line with up to 4 years of follow-up. Adverse events were recorded for each treatment group. Propensity score matching was effective in matching 124 CT-P13-treated and 124 reference infliximab-treated patients. Median treatment duration and drug retention were similar between CT-P13 and reference infliximab. Three-year retention rates (95% confidence interval [CI]) were 64.2% (53.5-73.0) for CT-P13 and 55.6% (42.9-66.6) for reference inflixim...Continue Reading

Associated Clinical Trials

References

Apr 24, 2007·Lancet·Jürgen Braun, Joachim Sieper
Nov 12, 2010·Annals of the Rheumatic Diseases·Pedro MachadoUNKNOWN Assessment of SpondyloArthritis international Society
Dec 10, 2013·British Journal of Anaesthesia·G N OkoliP Myles
Feb 20, 2014·Journal of Korean Medical Science·Tae-Jin LeeYeong-Wook Song
May 17, 2014·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Petra BajiValentin Brodszky
May 17, 2014·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Valentin BrodszkyMárta Péntek
Sep 24, 2015·Expert Review of Clinical Immunology·László GulácsiMárta Péntek
Sep 4, 2017·Annals of the Rheumatic Diseases·Jonathan KayUNKNOWN Task Force on the Use of Biosimilars to Treat Rheumatological Diseases
Oct 27, 2018·Nature Reviews. Rheumatology·Evrydiki KravvaritiPetros P Sfikakis
Nov 18, 2019·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Hyoun-Ah KimKichul Shin

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