Rethinking immunological privilege: implications for corneal and limbal stem cell transplantation

Molecular Medicine Today
K A Williams, D J Coster

Abstract

Immunological privilege operates within the normal eye by multiple passive and active mechanisms, including antigen sequestration, maintenance of an immunosuppressive local environment and induction of apoptotic death in infiltrating cells of the immune system. Ocular privilege might have developed to protect the eye from the collateral damage associated with an inflammatory response to invading pathogens. Nevertheless, corneal grafts do undergo irreversible immunological rejection and, furthermore, corneal graft rejection is very similar at a histological level to the rejection processes that operate in vascularized organ grafts. Ocular privilege is thus relative. The question arises as to how corneal grafts are rejected in the face of so many mechanisms designed to prevent immune responses from operating inside the eye--a question that is still essentially unanswered.

References

Oct 1, 1992·The British Journal of Ophthalmology·W AyliffeI V Hutchinson
Nov 1, 1992·The Journal of Cell Biology·Y GavrieliS A Ben-Sasson
Jan 1, 1990·Eye·S J Tuft, D J Coster
May 1, 1989·Ophthalmology·K R Kenyon, S C Tseng
Nov 1, 1985·Archives of Ophthalmology·R A WeiseA M Roth
Jul 30, 1971·American Journal of Ophthalmology·G Smolin, R A Hyndiuk
May 1, 1981·The Journal of Experimental Medicine·J W Streilein, J Y Niederkorn
Nov 17, 1995·Science·T S GriffithT A Ferguson
Jan 1, 1995·Eye·D F Larkin, K A Williams
Oct 19, 1995·Nature·D BellgrauR C Duke
Jul 1, 1993·Cornea·R A Thoft, J Sugar
Mar 19, 1996·Proceedings of the National Academy of Sciences of the United States of America·D L Vaux, A Strasser
Feb 1, 1997·The Journal of Clinical Investigation·P M StuartT A Ferguson
Apr 15, 1997·Proceedings of the National Academy of Sciences of the United States of America·J AllisonD L Vaux
May 1, 1997·Immunology Today·T S Griffith, T A Ferguson

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Citations

Mar 29, 2000·Survey of Ophthalmology·H S Dua, A Azuara-Blanco
Mar 13, 2003·Immunology and Cell Biology·Michael A ThielKeryn A Williams
Jan 29, 2000·Proceedings. Biological Sciences·C C ChanA J George
Aug 20, 2004·The British Journal of Ophthalmology·J PlskovaJ V Forrester
Apr 19, 2005·The British Journal of Ophthalmology·K A WilliamsD J Coster
Jan 22, 2002·The British Journal of Ophthalmology·J PlskováJ V Forrester
Oct 13, 2000·American Journal of Respiratory and Critical Care Medicine·A J GeorgeD F Larkin
Apr 16, 2004·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A J T George, D F P Larkin
Nov 25, 2003·Eye·D J Coster, K A Williams
May 21, 2010·Ocular Immunology and Inflammation·Jerry Y Niederkorn, D Frank P Larkin
Apr 21, 2004·Advances in Anatomic Pathology·Sonja KlebeM A Michael Rozenbilds

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