Rethinking inheritance, yet again: inheritomes, contextomes and dynamic phenotypes

BioRxiv : the Preprint Server for Biology
N. G. PrasadT.N.C. Vidya


In recent years, there have been many calls for an extended evolutionary synthesis, based in part upon growing evidence for non-genetic mechanisms of inheritance i.e. similarities in phenotype between parents and offspring that are not due to shared genes. While there has been an impressive marshalling of evidence for diverse forms of non-genetic inheritance (epigenetic, ecological, behavioural, symbolic), there have been relatively few studies trying to weld the different forms of inheritance into a common conceptual structure, a development that would be important to formalizing elements of the extended evolutionary synthesis. Here, we develop a framework for an extended view of inheritance and introduce some conceptual distinctions that we believe are important to this issue. In this framework, the phenotype is conceived of as a dynamic entity, its state at any point in time resulting from intertwined effects of previous phenotypic state, and of hereditary materials (DNA and otherwise) and environment. We contrast our framework with the standard gene-based view of inheritance, and also discuss our framework in the specific context of recent attempts to accommodate non-genetic inheritance within the framework of classical qua...Continue Reading

Related Concepts

Biological Evolution
Gene Delivery Systems
Epigenetic Process
Inheritance Mode

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