Rethinking interhemispheric imbalance as a target for stroke neurorehabilitation

Annals of Neurology
Jing XuSMARTS Study Group

Abstract

Patients with chronic stroke have been shown to have failure to release interhemispheric inhibition (IHI) from the intact to the damaged hemisphere before movement execution (premovement IHI). This inhibitory imbalance was found to correlate with poor motor performance in the chronic stage after stroke and has since become a target for therapeutic interventions. The logic of this approach, however, implies that abnormal premovement IHI is causal to poor behavioral outcome and should therefore be present early after stroke when motor impairment is at its worst. To test this idea, in a longitudinal study, we investigated interhemispheric interactions by tracking patients' premovement IHI for one year following stroke. We assessed premovement IHI and motor behavior five times over a 1-year period after ischemic stroke in 22 patients and 11 healthy participants. We found that premovement IHI was normal during the acute/subacute period and only became abnormal at the chronic stage; specifically, release of IHI in movement preparation worsened as motor behavior improved. In addition, premovement IHI did not correlate with behavioral measures cross-sectionally, whereas the longitudinal emergence of abnormal premovement IHI from the ac...Continue Reading

References

Jan 1, 1992·The Journal of Physiology·A FerbertC D Marsden
Dec 1, 1996·Journal of the Neurological Sciences·B BoroojerdiA Ferbert
Mar 3, 2004·Annals of Neurology·Nagako MuraseLeonardo G Cohen
Jun 29, 2004·Experimental Brain Research·John A Buford, Adam G Davidson
Dec 15, 2004·Archives of Neurology·Nick S Ward, Leonardo G Cohen
Jul 22, 2006·Lancet Neurology·Friedhelm C Hummel, Leonardo G Cohen
Nov 30, 2011·Restorative Neurology and Neuroscience·Dinesh G NairGottfried Schlaug
Nov 30, 2011·Restorative Neurology and Neuroscience·Erik H Hoyer, Pablo A Celnik
Dec 19, 2013·São Paulo Medical Journal = Revista Paulista De Medicina·Rubens José Gagliardi
May 27, 2014·Multivariate Behavioral Research·Joost R van Ginkel, Pieter M Kroonenberg
Sep 10, 2014·Nature Reviews. Neurology·Giovanni Di PinoVincenzo Di Lazzaro
Apr 19, 2015·Progress in Brain Research·Jitka Lüdemann-PodubeckáDennis Alexander Nowak
Jul 22, 2015·Brain Stimulation·Cathy M StinearWinston D Byblow
Sep 22, 2015·Frontiers in Cellular Neuroscience·Heidi M SchambraJohn W Krakauer
Nov 21, 2016·Neurophysiologie clinique = Clinical neurophysiology·Jean-Pascal Lefaucheur
Apr 8, 2017·Brain Stimulation·Michelle N McDonnell, Cathy M Stinear
Jun 2, 2017·Journal of Neurophysiology·Jing XuJörn Diedrichsen

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Citations

May 7, 2019·American Journal of Physical Medicine & Rehabilitation·April Pruski, Pablo Celnik
Mar 19, 2020·Journal of Neurophysiology·John CirilloWinston D Byblow
Apr 24, 2020·Neurorehabilitation and Neural Repair·Chih-Wei TangI-Hui Lee
Jul 22, 2020·Neurorehabilitation and Neural Repair·Teiji KawanoIchiro Miyai
Jul 30, 2020·Neuromodulation : Journal of the International Neuromodulation Society·Raffaella ChieffoLetizia Leocani
May 21, 2019·Stroke; a Journal of Cerebral Circulation·Manuel A Anaya, Meret Branscheidt
Jul 19, 2019·American Journal of Physical Medicine & Rehabilitation·April Pruski, Pablo Celnik
Nov 14, 2019·Current Treatment Options in Neurology·Laura A Malone, Lisa R Sun
Nov 28, 2020·Neurorehabilitation and Neural Repair·Jonathan S Tsay, Carolee J Winstein
Dec 16, 2020·Stroke; a Journal of Cerebral Circulation·Maria NazarovaVadim V Nikulin
Mar 12, 2021·Neurorehabilitation and Neural Repair·Brice T Cleland, Sangeetha Madhavan
May 6, 2021·Nature Communications·Eric MooshagianLawrence H Snyder
Jun 18, 2021·Stroke; a Journal of Cerebral Circulation·Chia-Lin KohLeeanne M Carey
Aug 13, 2021·Science Advances·Shahabeddin VahdatGary K Steinberg
Jan 16, 2021·Annals of Physical and Rehabilitation Medicine·Shenhao DaiDominic Pérennou

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