PMID: 11339386May 8, 2001Paper

Rethinking the role of urinary magnesium in calcium urolithiasis

Journal of Endourology
B F SchwartzM L Stoller

Abstract

The role of magnesium in urinary stone formation remains undefined. In vivo, magnesium inhibits stone formation in hyperoxaluric rats, and small clinical studies suggest a protective effect of magnesium supplementation in calcium oxalate stone formers. We performed a retrospective review of more than 7,000 stone patients to see if there is a relation between urinary magnesium and other stone risk variable constituents. A national database of stone formers categorized by residential ZIP code was queried, and, using strict inclusion criteria, 2,147 patients having pure calcium oxalate stones were identified. There were 1,912 (89%) eumagnesuric (43-246 mg/24 hours) and 235 (11%) hypomagnesuric (<43 mg/24 hours) patients. Patients with decreased urinary magnesium excretion had significantly less daily urine excretion of citrate, calcium, oxalate, uric acid, and sodium than the eumagnesuric group (p < 0.0001). Stone recurrence was slightly more common in the hypomagnesuric group, although the difference was not statistically significant. The percentage of patients voiding <1 L of urine per day was significantly higher in the hypomagnesuric group. In the eumagnesuric group, males outnumbered females 2:1, whereas hypomagnesuric patien...Continue Reading

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Citations

Nov 13, 2013·Biological Trace Element Research·Abdul Haleem PanhwarKapil Dev Brahman
Jul 9, 2002·Urology·Bradley F SchwartzMarshall L Stoller
Apr 7, 2005·Urologia Internationalis·Diana J ZimmermannAlbrecht Hesse
Sep 4, 2015·Nature Reviews. Urology·Krishna RamaswamyMarshall L Stoller
Jun 1, 2016·Urolithiasis·Muhammad Waqas IqbalMichael E Lipkin
May 6, 2020·The Journal of Clinical Endocrinology and Metabolism·Federica SaponaroFilomena Cetani
Apr 2, 2003·Urological Research·E Olavi KajanderEnrique Garcia-Cuerpo
Dec 6, 2018·International Urology and Nephrology·Sanaz TavasoliFahimeh Bagheri Amiri

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