Rethinking Thymic Tolerance: Lessons from Mice

Trends in Immunology
Sarah InglesfieldGraham Anderson

Abstract

In the thymus, distinct cortex and medulla areas emphasize the division of labor in selection events shaping the αβT cell receptor repertoire. For example, MHC restriction via positive selection is a unique property of epithelial cells in the thymic cortex. Far less clear are the events controlling tolerance induction in the medulla. By acting in concert through multiple roles, including antigen production/presentation and chemokine-mediated control of migration, we propose that medullary epithelium and dendritic cells collectively enable the medulla to balance T cell production with negative selection and Foxp3+ regulatory T cell (Treg) development. We examine here the features of these medullary resident cells and their roles in T cell tolerance, and discuss how imbalance in the thymus can result in loss of T cell tolerance.

Citations

Jan 29, 2020·Annual Review of Immunology·Peter A SavageChristine H Miller
Jul 22, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mohamed BenhammadiClaude Perreault
Aug 28, 2020·Immunological Reviews·Mia Hamilton JeeCharlotte Menné Bonefeld
Apr 30, 2020·Genome Medicine·Jean-David LaroucheClaude Perreault
Mar 11, 2020·Frontiers in Immunology·Valérie JanelleJean-Sébastien Delisle
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Feb 23, 2020·Science·Jong-Eun ParkSarah A Teichmann
Feb 13, 2020·Inflammation and Regeneration·Takehito OnoTomoki Nakashima
Jan 16, 2021·Trends in Immunology·Chen LiuHongbo Hu
Nov 3, 2020·Frontiers in Psychiatry·Silvia Sánchez-Ramón, Florence Faure
Feb 25, 2021·Open Biology·Ryo MorimotoThomas Boehm
Mar 26, 2021·Frontiers in Immunology·Sara Montero-HerradónAgustín G Zapata
Apr 20, 2021·Trends in Genetics : TIG·Pierre PontarottiJulien Paganini
May 4, 2021·Journal of Immunology Research·Masayoshi AosasaMujo Kim

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