Rethinking urinary antibiotic breakpoints: analysis of urinary antibiotic concentrations to treat multidrug resistant organisms

BMC Research Notes
Daniel B ChastainKayla R Stover

Abstract

The present study analyzed whether renally eliminated antibiotics achieve sufficient urinary concentrations based on their pharmacokinetic/pharmacodynamic principles to effectively eradicate organisms deemed resistant by automated susceptibility testing. Lower median minimum inhibitory concentrations against enterobacteriaceae were noted for ceftriaxone, cefepime, and doripenem when comparing Etest® to Vitek®. All Pseudomonas aeruginosa isolates were susceptible to cefepime, ciprofloxacin, and doripenem with both susceptibility methods, but higher median minimum inhibitory concentrations were observed with Etest®. Urine concentrations/time profiles were calculated for standard doses of ceftriaxone, cefepime, doripenem, and ciprofloxacin. The data presented in the current study suggests high urine concentrations of antibiotics may effectively eradicate bacteria which were determined to be resistant per in vitro susceptibility testing.

References

Mar 1, 1992·Antimicrobial Agents and Chemotherapy·R H BarbhaiyaR R Martin
Mar 1, 1985·Journal of Clinical Pharmacology·D C BrittainH C Neu
Nov 28, 1974·The New England Journal of Medicine·T A StameyY C Lowery
Dec 1, 1996·The Annals of Pharmacotherapy·M A Wynd, J A Paladino
Jul 24, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·J D Turnidge
Dec 5, 2006·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Paul G AmbroseGeorge L Drusano
Nov 28, 2008·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Helen W BoucherJohn Bartlett
Feb 27, 2009·Clinical Therapeutics·S James Matthews, Jason W Lancaster
Jun 17, 2009·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·David L Paterson, Daryl D Depestel
Oct 28, 2009·Pharmacotherapy·Kristi M KuperAudrey Wanger
Mar 24, 2011·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·John D Turnidge, UNKNOWN Subcommittee on Antimicrobial Susceptibility Testing of the Clinical and Laboratory Standards Institute
Apr 16, 2014·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Gabriel Trova CubaCarlos Roberto Veiga Kiffer
Jan 12, 2016·Open Forum Infectious Diseases·Larissa GrigoryanBarbara W Trautner
Apr 16, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Tamar F BarlamKavita K Trivedi
Jul 16, 2016·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Andre C KalilJan L Brozek
Dec 29, 2016·The American Journal of Emergency Medicine·Maryann Mazer-AmirshahiLarissa May

❮ Previous
Next ❯

Citations

Feb 2, 2019·International Journal of Environmental Research and Public Health·Chia-Hung HuangChao-Bin Yeh
Dec 17, 2020·Antibiotics·Nicole Griffith, Larry Danziger

❮ Previous
Next ❯

Software Mentioned

Etest
Vitek

Related Concepts

Related Feeds

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Carbapenems (ASM)

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Carbapenems

Carbapenems are members of the beta lactam class of antibiotics and are used for the treatment of severe or high-risk bacterial infections. Discover the latest research on carbapenems here.

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.