Reticular and erosive oral lichen planus have a distinct metabolomic profile: A preliminary study using gas chromatography-mass spectrometry

Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology
Aline Fernanda CruzRicardo Santiago Gomez

Abstract

Oral Lichen Planus is a chronic inflammatory disorder that affects the oral mucosa, with the reticular and erosive forms representing the primary clinical variants of the disease. Previous studies have shown that metabolic alterations may well be involved in the pathogenesis of the disease; however, the molecular mechanisms related to the clinicopathological differences between erosive and reticular forms remain unknown. A comparative metabolomic analysis was performed on formalin-fixed and paraffin-embedded tissue samples of erosive (n = 6) and reticular (n = 10) oral lichen planus using gas chromatography-mass spectrometry. The metabolomic analysis showed a distinct profile between the two clinical variants. Five metabolites (cyclohexanamine, glycine, mannitol/sorbitol, methyl palmitate and trehalose) were significantly diminished in erosive oral lichen planus as compared to the reticular form. Reticular and erosive forms of oral lichen planus have a distinct metabolic profile. However, further studies using a large number of fresh tissue samples are necessary to confirm this data.

References

Nov 15, 2000·Journal of Oral and Maxillofacial Surgery : Official Journal of the American Association of Oral and Maxillofacial Surgeons·S Silverman
Feb 18, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Zhi ZhongJohn J Lemasters
Oct 20, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S WarnakulasuriyaI van der Waal
Oct 25, 2008·Brazilian Dental Journal·Juliana M Caldeira BrantLuciana V Rodrigues
May 21, 2009·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Gang ZhouHong-mei Zhou
Jul 31, 2012·Toxicology and Applied Pharmacology·Noha M SaeedAshraf B Abdel-Naim
May 28, 2015·Annals of the New York Academy of Sciences·Stefano Cacciatore, Massimo Loda
Jul 13, 2016·Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology·Yi-Shing Lisa ChengSusan Muller
Sep 10, 2016·BMC Medicine·Arnald AlonsoUNKNOWN IMID Consortium
Oct 25, 2016·Archives of Oral Biology·Xu-Zhao LiLiang-Zhen Xie
Jan 12, 2017·Molecular Cancer Research : MCR·Stefano CacciatoreMassimo Loda
Feb 22, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xu-Yan YangXiao-Dong Yin
Nov 22, 2017·Signal Transduction and Targeted Therapy·Ting LiuShao-Cong Sun
May 16, 2018·Nucleic Acids Research·Jasmine ChongJianguo Xia
Sep 16, 2018·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xu-Yan YangShuai-Nan Zhang

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Academy of Dermatology
F AyalaR Orlando
Annales de dermatologie et de vénéréologie
J Cendras, J-M Bonnetblanc
Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
D E Kyrmizakis, C E Papadakis
Avances en odontoestomatologia
J V BaganC Roig
Nederlands tijdschrift voor geneeskunde
T C Vriezen
© 2022 Meta ULC. All rights reserved