Reticulated platelets and immature platelet fraction: Clinical applications and method limitations

International Journal of Laboratory Hematology
Mauro ButtarelloMario Plebani

Abstract

So-called "reticulated" or "immature platelets," which are newly released into the circulation, are more reactive than mature platelets, contain more RNA, and can be counted using flow cytometry after staining with thiazole orange or using some fully automated hematology analyzers, albeit with numerical disagreement. This review provides an overview of the state of the art of available technology for measuring immature or reticulated platelets (RP) with preanalytical (time stability, biological variation), analytical (methods, imprecision), and postanalytical (reference range) limitations. We also analyzed the clinical conditions in which immature/RP can be considered a diagnostic or prognostic tool (ie, differential diagnosis of thrombocytopenia, recovery after bone marrow or stem cell transplantation, risk assessment in cardiovascular diseases, response to antiplatelet drugs). They might also be of clinical utility in other settings but with lower evidence. The lack of a specific reference method and universal control material, as well as dependency of results on the measurement technique used, calls for different reference intervals and compromises comparison between clinical studies carried out using different analytical me...Continue Reading

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Citations

Nov 26, 2020·Journal of Clinical Medicine·Noé CorpatauxWillibald Hochholzer
Dec 9, 2020·International Journal of Laboratory Hematology·Olga Perelshtein BrezinovAvishag Laish-Farkash
Jan 5, 2021·Frontiers in Medicine·Hollie M Reeves, Robert W Maitta
Jun 11, 2021·Cellular and Molecular Bioengineering·Maaike S A JongenJonathan West
Aug 24, 2021·Journal of Cardiovascular Pharmacology and Therapeutics·Belay Tesfamariam
Aug 27, 2021·British Journal of Haematology·Keith GomezUNKNOWN British Society for Haematology Guidelines
Sep 10, 2021·Transactions of the Royal Society of Tropical Medicine and Hygiene·Visula AbeysuriyaSanjay de Mel

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