Reticulocyte hemoglobin content (MCHr) in the assessment of iron deficient erythropoiesis in inflammatory bowel disease

Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver
Eloísa UrrechagaJosé L Cabriada

Abstract

In conditions associated with inflammation, biochemical parameters alone could be inadequate for assessing iron status. We investigated the potential utility of mean reticulocyte hemoglobin content (MCHr) in the assessment of the erythropoiesis status in inflammatory bowel disease (IBD). We recruited 124 anemic outpatients with IBD. Serum iron, transferrin and ferritin were tested. Complete blood counts were performed on a CELL-DYN Sapphire analyzer (Abbott Diagnostics). Differences among groups were assessed using analysis of variance, considering P < 0.05 to be significant. Receiver operating characteristic analysis was used to assess the diagnostic performance of MCHr for detecting iron deficient erythropoiesis. The reference used as an indicator of insufficient iron availability was transferrin saturation <20%. Overall, 47.6% of the patients had iron deficiency anemia (IDA) and 31.5% anemia of chronic disease (ACD), while the others (20.9%) had mixed anemia. Patients with ACD or mixed anemia showed functional iron deficiency: normal or high ferritin and low MCHr. The area under curve was 0.858 (95% CI 0.742-0.942), considering a cut off 30.3 pg, the sensitivity was 82.2%, specificity 83.3%. MCHr provides information on iron...Continue Reading

Citations

May 29, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Eloísa Urrechaga, Johannes J M L Hoffmann
Dec 12, 2019·Scandinavian Journal of Clinical and Laboratory Investigation·Eloísa UrrechagaFrancisco J Aguayo
Jun 20, 2020·Blood·Aryeh ShanderLawrence T Goodnough
Dec 15, 2020·Current Opinion in Gastroenterology·Leo Alexandre, Simon S M Chan
Apr 16, 2021·Anesthesiology·Nicole R GuinnSteven M Frank

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anemia

Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Related Papers

Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)
Eloísa Urrechaga IgartuaJesús F Escanero
Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis
Elisabeth Aardal ErikssonJohannes J M L Hoffmann
© 2022 Meta ULC. All rights reserved