Reticulocyte subpopulations and reticulocyte maturity index (RMI) rise as body iron status falls

American Journal of Hematology
J W Choi, S H Pai

Abstract

To investigate the influence of body iron status on reticulocyte subpopulations and reticulocyte maturity index (RMI), we measured serum iron markers, fluorescent intensity of reticulocytes, and serum transferrin receptor (sTfR) concentrations in 374 females aged 14-19 years. Reticulocyte subpopulations were analyzed by flow cytometry, and sTfR concentration was measured by enzyme immunoassay. There were no significant differences in the values of reticulocyte subpopulations and RMI between ferritin alone-depleted group and healthy controls. However, middle- and high-fluorescence reticulocytes and RMI were significantly higher in both the serum iron- and serum ferritin-depleted groups than in the ferritin alone-depleted group. Middle-fluorescence reticulocytes and RMI increased gradually as the body iron store was depleted and were 3.4- and 3.6-fold higher, respectively, than normal controls, when the subjects attained a frank iron-deficiency anemia. There were no significant changes in the values of red blood cells or total reticulocyte counts during iron-depleted states. The mean value of sTfR (3.98 mg/l) in the subjects with RMI > or = 1.5% was significantly higher than that (2.26 mg/l) in the subjects with RMI < 1.5% (P < 0...Continue Reading

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Citations

Nov 15, 2005·Journal of Pharmacokinetics and Pharmacodynamics·Nidal H Al-HunitiPeter Veng-Pedersen
Apr 12, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Jong Weon Choi, Byong Kwan Son
Feb 19, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yves Beguin
Jul 9, 2008·Clinical Chemistry and Laboratory Medicine : CCLM·Enni MäkeläPäivi M Lähteenmäki
Mar 13, 2010·Laboratory Hematology : Official Publication of the International Society for Laboratory Hematology·Mariacaterina MaconiPaolo Danise
Sep 17, 2003·Clinical and Laboratory Haematology·A Torres GomezM A Alvarez
May 14, 2011·Journal of Clinical Laboratory Analysis·Eloísa UrrechagaJesús F Escanero
Dec 14, 2006·Journal of Pediatric Hematology/oncology·M Angeles Vázquez LópezAntonio Muñoz Hoyos
Dec 22, 2005·American Journal of Hematology·F KrügnerM F Sonati
Jul 28, 2018·Frontiers in Physiology·Elina OvchynnikovaEmile van den Akker

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