Reticulospinal neurons receive direct spinobulbar inputs during locomotor activity in lamprey

Journal of Neurophysiology
James F Einum, J T Buchanan

Abstract

Reticulospinal neurons of the lamprey brain stem receive rhythmic input from the spinal cord during locomotor activity. The goal of the present study was to determine whether such spinal input has a direct component to reticulospinal neurons or depends on brain stem interneurons. To answer this question, an in vitro lamprey brain stem-spinal cord preparation was used with a diffusion barrier placed caudal to the obex, separating the experimental chamber into two baths. Locomotor activity was induced in the spinal cord by perfusion of d-glutamate or N-methyl-dl-aspartate into the spinal cord bath. The brain stem bath was first perfused with normal Ringer solution followed by a high-Ca(2+), -Mg(2+) solution, which reduced polysynaptic transmission. The amplitudes of membrane potential oscillations of reticulospinal neurons in the posterior and middle rhombencephalic reticular nuclei (PRRN and MRRN, respectively) recorded with sharp intracellular microelectrodes did not significantly change from normal to high-divalent solution. This finding suggests a large part of the spinal input creating the oscillations is direct to the reticulospinal neurons. Application of strychnine to the high-Ca(2+), -Mg(2+) solution decreased membrane p...Continue Reading

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Citations

Aug 25, 2007·Brain Research Reviews·James T Buchanan, James F Einum
Nov 26, 2010·Progress in Neurobiology·Olivia J MullinsW Otto Friesen
Jan 25, 2018·Journal of Neurophysiology·James T Buchanan
Mar 4, 2005·Journal of Neurophysiology·James F Einum, James T Buchanan
May 26, 2010·Nature Neuroscience·Matthew C Tresch
Jan 1, 2006·SIAM Journal on Applied Dynamical Systems·Christina Ambrosio-MouserAmitabha Bose
Jul 14, 2006·Journal of Neurophysiology·James F Einum, James T Buchanan
May 4, 2018·Frontiers in Neural Circuits·Robert M Brownstone, Jeremy W Chopek
Oct 24, 2017·Current Biology : CB·Shreyas M SuryanarayanaSten Grillner

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