Retiform hemangioendotheliomas usually do not express D2-40 and VEGFR-3

The American Journal of Dermatopathology
Amy ParsonsO P Sangueza

Abstract

Retiform hemangioendothelioma (RH) is a rare vascular neoplasm most often occurring in the limbs of middle-aged females. This entity is characterized by infiltrative vascular spaces arranged in a pattern similar to the rete testis. RH differs from angiosarcoma by lacking cytologic atypia and high mitotic rates. This neoplasm frequently recurs but rarely metastasizes. RH tumor cells react with vascular endothelial markers CD31, CD34, and factor VIII-related antigen. A review of the English literature provides only one attempt at staining RH with D2-40, a marker of endothelium of lymphatic vessels, which was negative, and one reported staining of RH with lymphatic endothelial marker VEGFR-3, which was positive. The etiology of RH is unknown. RH has previously been considered closely related to Dabska tumors, which are positive for lymphatic endothelial marker D2-40. We stained 4 RHs with mouse monoclonal antibodies against D2-40 and CD31 and 3 of the 4 RHs with vascular endothelial growth factor receptor 3 (VEGFR-3), to further evaluate whether RH had lymphatic differentiation, in addition to vascular differentiation. Three of the 4 RH biopsies failed to demonstrate D2-40, none expressed VEGFR-3, whereas CD31 was strongly positiv...Continue Reading

References

Dec 1, 1996·The American Journal of Dermatopathology·D DukeL M Cohen
Oct 12, 2001·Microscopy Research and Technique·J P SleemanP Baumann
Apr 16, 2002·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Harriette J KahnAlexander Marks
Apr 3, 2004·Journal of Cutaneous Pathology·Folker E FrankeThomas Mentzel
May 28, 2005·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Larisa V DebelenkoHarry P W Kozakewich
Sep 24, 2005·Journal of Cutaneous Pathology·Dongfeng TanThaer Khoury
May 4, 2006·Advances in Anatomic Pathology·Nelson G Ordóñez
Feb 8, 2007·The American Journal of Dermatopathology·Amal H A GomaaJag Bhawan
Mar 23, 2007·Virchows Archiv : an International Journal of Pathology·Torsten HansenDetlef Katenkamp

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Citations

May 23, 2008·The American Journal of Dermatopathology·Angel Fernandez-Flores
Oct 5, 2010·The American Journal of Dermatopathology·Ziad Khamaysi, Reuven Bergman
Sep 15, 2011·The American Journal of Dermatopathology·Anne-Fore AlbertiniSylvie Fraitag
May 13, 2014·Indian Journal of Ophthalmology·Yasser H Al-FakyMohammed O Al-Sohaibani
Jan 19, 2013·Seminars in Diagnostic Pathology·Luis Requena, Heinz Kutzner
Jul 24, 2012·Journal of Comparative Pathology·E D Lombardini, B A Summers
Aug 30, 2008·The Journal of Foot and Ankle Surgery : Official Publication of the American College of Foot and Ankle Surgeons·Daniel YarmelBenjamin Chang
Jul 25, 2008·Pathology, Research and Practice·Angel Fernandez-Flores
Aug 14, 2009·Journal of Cutaneous Pathology·Michael EmbergerBernhard Zelger
Nov 22, 2011·Journal of Cutaneous Pathology·David Lukas Wachter, Abbas Agaimy
Apr 4, 2017·Indian Journal of Dermatology, Venereology and Leprology·Yang TanXia Lei
Sep 17, 2017·Journal of Clinical Pathology·Elina ShustefPhyu P Aung
Mar 28, 2013·Applied Immunohistochemistry & Molecular Morphology : AIMM·Nelson G Ordóñez
May 21, 2014·The American Journal of Dermatopathology·Li-qiang ZhengJing-Yuan Fan
Aug 14, 2012·Advances in Anatomic Pathology·Nelson G Ordóñez
Nov 17, 2016·Journal of the Korean Association of Oral and Maxillofacial Surgeons·Il-Kyu KimSeung-Hoon Park
Apr 3, 2018·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Louis P Dehner, Alejandro A Gru
Feb 8, 2020·Indian Journal of Pathology & Microbiology·Anindita MondalChhanda Datta
Jul 4, 2020·The American Journal of Dermatopathology·Pedro Vilas BoasLuis Requena
Aug 4, 2021·The Journal of International Medical Research·Mingyue ZhangYing Yue

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