Retinal adaptation responses revealed by global flash multifocal electroretinogram are dependent on the degree of myopic refractive error

Vision Research
Jennifer C ChenKatrina L Schmid

Abstract

There is evidence that the inner retina is involved in eye growth control processes and the development of myopia. We sought to investigate the response dynamics of the inner retina of adult emmetropes and myopes using the global flash multifocal electroretinogram (mfERG) paradigm. Fourteen myopes and 10 emmetropic subjects (mean age: 21.0+/-2.8 years) underwent mfERG testing using VERIS 5.1.5X. The global flash stimulus array consisted of 103-scaled hexagons which flickered according to a pseudorandom binary m-sequence (2(13)-1). The stimulation sequence was modified by inserting three frames, a dark frame, a global (full screen) flash, and another dark frame. The amplitude and implicit time of the two distinct waveform features, an early direct component (DC) and a later induced component (IC) of the first-order kernel were analyzed. Retinal responses were averaged over rings of increasing eccentricity, or into nasal and temporal hemifields. There was a significant correlation between the DC and IC response amplitude and myopic refractive error, i.e., the greater the myopic error, the greater the response amplitude. However, when comparing between the two refractive error groups, DC and IC response amplitudes of emmetropes an...Continue Reading

References

Nov 1, 1976·American Journal of Optometry and Physiological Optics·I L Bailey, J E Lovie
Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R A StoneP M Iuvone
Jan 1, 1971·American Journal of Ophthalmology·B J Curtin, D B Karlin
Jan 1, 1996·Current Eye Research·T FujikadoT Omoto
May 1, 1997·Australian and New Zealand Journal of Ophthalmology·P L MegawM K Boelen
Jul 31, 1998·Australian and New Zealand Journal of Ophthalmology·J A BeresfordD P Crewther
Oct 20, 1998·Progress in Retinal and Eye Research·L Wachtmeister
May 27, 1999·Vision Research·D C HoodJ G Robson
Nov 24, 1999·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·B KremserG F Kieselbach
Aug 5, 2000·Progress in Retinal and Eye Research·D C Hood
Mar 27, 2001·The British Journal of Ophthalmology·Y ShimadaW Fung
Mar 19, 2003·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·H L Chan, N Mohidin
Oct 16, 2003·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Ian G Morgan
Apr 24, 2004·Documenta Ophthalmologica. Advances in Ophthalmology·Paul Witkovsky
May 7, 2004·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Michaela Bitzer, Frank Schaeffel
Jun 30, 2004·Investigative Ophthalmology & Visual Science·Nicola S LoganMark C M Dunne
Mar 3, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yoshiaki ShimadaErich E Sutter
Apr 28, 2005·Developmental Neuroscience·Suraj P BhatReginald G Ariyasu
Aug 5, 2005·Visual Neuroscience·Jodi Rymer, Christine F Wildsoet
Aug 13, 2005·Vision Research·Jennifer C ChenKatrina L Schmid
Nov 24, 2005·Investigative Ophthalmology & Visual Science·Beatrix FeiglPeter Swann

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Citations

Feb 21, 2009·Documenta Ophthalmologica. Advances in Ophthalmology·Charlotte M Poloschek, Michael Bach
Feb 18, 2011·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Henry Ho-Lung ChanPatrick Ho-wai Chu
Dec 15, 2010·Vision Research·Wing-cheung HoHenry Ho-lung Chan
Dec 7, 2019·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Philip R K TurnbullJohn R Phillips
Nov 18, 2021·Documenta Ophthalmologica. Advances in Ophthalmology·Satish Kumar GuptaPavan Kumar Verkicharla

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Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
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