Retinal and choroidal circulation determined by optical coherence tomography angiography in patient with amyloidosis

BMJ Case Reports
Masami TeiTomohiro Iida

Abstract

A 43-year-old woman who was diagnosed with the cryopyrine-associated periodic syndrome (CAPS) with severe renal failure and heart failure due to amyloid accumulation was examined by swept source optical cohernce tomography (OCT) (SS-OCT; DRI-OCT, Topcon, Tokyo, Japan) and optical coherence tomography angiography (OCTA) (RTVue XR Avanti, Optovue, Fremont, CA). Her best-corrected visual acuity was 20/40 OD and 20/25 OS. A hyporeflective band of about 100 µm thickness was seen just inferior to the retinal pigment epithelium in the cross-sectional SS-OCT images, but the deeper choroidal structures were clearly visible. In the OCTA images, the density of the retinal capillaries in the superficial and deep capillary plexus slabs were reduced, and no signals of the choroidal capillary slab was detected after removing the projection artefacts. The accumulation of amyloid can cause a reduction of both the retinal and choroidal capillary circulations although the circulation in the larger vessels are preserved.

References

Sep 1, 1971·Archives of Ophthalmology·M O Ts'o, J W Bettman
Sep 27, 2000·American Journal of Ophthalmology·A PeceR Brancato
May 10, 2008·European Journal of Ophthalmology·T HattoriN Yasuda
Oct 1, 2015·Retinal Cases & Brief Reports·C Nathaniel RoybalDavid Sarraf
Feb 18, 2017·Saudi Journal of Ophthalmology : Official Journal of the Saudi Ophthalmological Society·Gianluca ScuderiSanti Maria Recupero
Mar 23, 2017·Case Reports in Ophthalmological Medicine·Takaaki AndoShuichi Yamamoto
Apr 17, 2017·Ophthalmology·Pradeep VenkateshRajpal Vohra

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Citations

Dec 18, 2020·The British Journal of Ophthalmology·Miguel Ángel ZapataJose García-Arumí
Jul 23, 2021·Progress in Retinal and Eye Research·Raphael LejoyeuxJay Chhablani
Jun 26, 2021·Retinal Cases & Brief Reports·Annelise N GonçalvesRodrigo Jorge

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