Retinal and Choroidal Folds in Papilledema

Investigative Ophthalmology & Visual Science
Patrick SibonyOCT Substudy Group for the NORDIC Idiopathic Intracranial Hypertension Treatment Trial

Abstract

To determine the frequency, patterns, associations, and biomechanical implications of retinal and choroidal folds in papilledema due to idiopathic intracranial hypertension (IIH). Retinal and choroidal folds were studied in patients enrolled in the IIH Treatment Trial using fundus photography (n = 165 study eyes) and spectral-domain optical coherence tomography (SD-OCT; n = 125). We examined the association between folds and peripapillary shape, retinal nerve fiber layer (RNFL) thickness, disc volume, Frisén grade, acuity, perimetric mean deviation, intraocular pressure, intracranial pressure, and refractive error. We identified three types of folds in IIH patients with papilledema: peripapillary wrinkles (PPW), retinal folds (RF), and choroidal folds (CF). Frequency, with photos, was 26%, 19%, and 1%, respectively; SD-OCT frequency was 46%, 47%, and 10%. At least one type of fold was present in 41% of patients with photos and 73% with SD-OCT. Spectral-domain OCT was more sensitive. Structural parameters related to the severity of papilledema were associated with PPW and RF, whereas anterior deformation of the peripapillary RPE/basement membrane layer was associated with CF and RF. Folds were not associated with vision loss at ...Continue Reading

Associated Clinical Trials

Citations

Jan 19, 2016·Ophthalmology·Patrick A SibonyUNKNOWN OCT Substudy Group of the NORDIC Idiopathic Intracranial Hypertension Treatment Trial
Jan 4, 2017·American Journal of Ophthalmology·Mark J KupersmithUNKNOWN OCT Sub-Study Group for the NORDIC Idiopathic Intracranial Hypertension Treatment Trial
Dec 9, 2016·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Thomas H MaderAndrew G Lee
Apr 19, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Luca ZatreanuMark J Kupersmith
Jan 29, 2017·The British Journal of Ophthalmology·Michael WallUNKNOWN NORDIC Idiopathic Intracranial Hypertension Study Group
Jul 13, 2018·Asia-Pacific Journal of Ophthalmology·Fiona CostelloSteffen Hamann
Dec 6, 2019·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Deepak SoniAnubha Rathi
Oct 22, 2019·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Laura A GaldamezWilliam J Tarver
Feb 9, 2020·Experimental Physiology·Igor B MekjavicPolona Jaki Mekjavic
Apr 20, 2016·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·John J Chen, Jonathan D Trobe
Oct 5, 2019·Continuum : Lifelong Learning in Neurology·Matthew J Thurtell
Jun 15, 2017·Case Reports in Ophthalmology·Takaki SatoTsunehiko Ikeda
Oct 5, 2019·Continuum : Lifelong Learning in Neurology·Fiona Costello, James N Scott
Jun 27, 2020·Frontiers in Neurology·David Moreno-AjonaJan Hoffmann
Jul 19, 2019·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Laura P PardonNimesh B Patel
Aug 26, 2020·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sevim TürayBüşra Cihan
Dec 6, 2020·Current Opinion in Neurology·Yan Yan, Yaping Joyce Liao
Feb 2, 2021·Current Eye Research·Xiangxiang LiuNingli Wang
Sep 11, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Patrick A SibonyRandy H Kardon
Mar 26, 2021·Neuro-ophthalmology·F CostelloUNKNOWN Optic Disc Drusen Studies Consortium
Aug 30, 2020·Ophthalmology Retina·Prem Nichani, Jonathan A Micieli
May 28, 2019·Ultrasound in Medicine & Biology·Boran ZhouXiaoming Zhang
Sep 22, 2020·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Mark J Kupersmith, Patrick A Sibony

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