Retinal atrophy in relation to visual functioning and vision-related quality of life in patients with multiple sclerosis

Multiple Sclerosis : Clinical and Laboratory Research
Lisanne J BalkAxel Petzold

Abstract

Inner retinal layer atrophy in patients with multiple sclerosis (MS) has been validated as a structural imaging biomarker for neurodegeneration. To determine how retinal layer thickness relates to high-contrast visual acuity (HCVA), low-contrast visual acuity (LCVA) and vision-related quality of life (QoL) and to investigate the effect of previous episodes on MS-associated optic neuritis (MSON). Spectral-domain optical coherence tomography (SD-OCT) was performed in 267 patients with MS. Images were segmented for the peripapillary retinal nerve fiber layer (pRNFL) and the macular ganglion cell inner plexiform layer (GCIPL). Ophthalmological evaluations included history of MSON, HCVA, LCVA, and vision-related QoL. Independent of MSON, HCVA and LCVA were significantly associated with pRNFL and GCIPL thicknesses. Vision-related QoL was positively associated with pRNFL (β = 0.92, p = 0.06) and GCIPL (β = 0.93, p = 0.02) thicknesses. These associations were independent of MSON. Not only binocular but also monocular atrophy of the inner retinal layers was associated with lower vision-related QoL. This study showed that retinal atrophy has a significant impact on visual functioning in patients with MS. OCT may therefore provide useful ...Continue Reading

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Citations

Aug 4, 2018·Journal of Neurology·Caspar B SeitzVinzenz Fleischer
Apr 3, 2019·Investigative Ophthalmology & Visual Science·Jenny A Nij BijvankLaurentius J van Rijn
Nov 20, 2019·Journal of Neurology, Neurosurgery, and Psychiatry·Axel PetzoldGordon T Plant
Jan 17, 2019·Rehabilitation Nursing : the Official Journal of the Association of Rehabilitation Nurses·Pamela NewlandMarjorie Skubic
Jan 9, 2021·Frontiers in Neurology·Soo-Hyun ParkNam-Hee Kim
Jan 12, 2021·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Jenny A Nij BijvankAxel Petzold
Feb 18, 2020·Vision Research·J A Nij BijvankL J van Rijn

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