Retinal bipolar cell types differ in their inventory of ion channels

Visual Neuroscience
Elena Ivanova, Frank Müller

Abstract

Bipolar cells were recorded in rat retinal slices to study the distribution of hyperpolarization-activated and cyclic nucleotide-gated (HCN) channels. Patch-clamp whole cell measurements were combined with intracellular filling and recorded cells were morphologically identified. HCN channel isoforms HCN1-4 are differentially expressed in bipolar cells. Each bipolar cell type has a characteristic inventory of HCN channels. The combination of HCN channel currents and other voltage-gated currents can be used as a kind of "finger print" to electrophysiologically identify and classify bipolar cell types. Using this approach of combined electrophysiological and morphological classification we could identify a new ON-cone bipolar cell type.

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Citations

Dec 20, 2008·Visual Neuroscience·Jinjuan Cui, Zhuo-Hua Pan
May 10, 2007·Journal of Neurophysiology·Sherwin C Lee, Andrew T Ishida
Jan 11, 2014·PloS One·Yuan PanSheila A Baker
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