Retinal Blood Velocity and Flow in Early Diabetes and Diabetic Retinopathy Using Adaptive Optics Scanning Laser Ophthalmoscopy

Journal of Clinical Medicine
Cherilyn Mae A PalochakAmani A Fawzi

Abstract

Using adaptive optics scanning laser ophthalmoscopy (AOSLO), we measured retinal blood velocity and flow in healthy control eyes and eyes of diabetic patients with or without retinopathy. This cross-sectional study included 39 eyes of 30 patients with diabetes (DM) with mild non-proliferative diabetic retinopathy (NPDR) or without retinopathy (DM no DR) and 21 eyes of 17 healthy age-matched controls. Participants were imaged with a commercial optical coherence tomography angiography (OCTA) device (RTVue-XR Avanti) and AOSLO device (Apaeros Retinal Imaging System, Boston Micromachines). We analyzed AOSLO-based retinal blood velocity and flow, and OCTA-based vessel density of the superficial (SCP), deep retinal capillary plexus (DCP), and full retina. Retinal blood velocity was significantly higher in eyes with DM no DR and lower in NPDR across all vessel diameters compared to controls. Retinal blood flow was significantly higher in DM no DR and lower in NPDR in vessel diameters up to 60 μm compared to controls. When comparing flow outliers (low-flow DM no DR eyes and high-flow NPDR eyes), we found they had a significantly different retinal vessel density compared to the remaining eyes in the respective groups. Retinal blood velo...Continue Reading

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Citations

May 12, 2020·Investigative Ophthalmology & Visual Science·Sonja G KarstEduardo V Navajas
May 30, 2020·Journal of Clinical Medicine·Hsin-Yu YaoHsiang-Chen Wang
Jun 7, 2020·Journal of Clinical Medicine·Jacqueline ChuaLeopold Schmetterer
Oct 1, 2020·Scientific Reports·Raymond L WarnerStephen A Burns
Dec 2, 2020·Eye·Engin AkyolAndrew J Lotery
Aug 14, 2020·Progress in Retinal and Eye Research·Jackson ScharfDavid Sarraf
Jun 7, 2021·Survey of Ophthalmology·Elise BakkerMichel Paques
May 19, 2021·Translational Vision Science & Technology·Rachelle KochJorge G Arroyo
May 19, 2021·Translational Vision Science & Technology·Jehwi JeonPilhan Kim
Jun 26, 2021·Annual Review of Vision Science·Stephen A BurnsThomas J Gast
Feb 25, 2021·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Chui Ming Gemmy CheungSobha Sivaprasad
Dec 1, 2021·Investigative Ophthalmology & Visual Science·Raymond L WarnerStephen A Burns
Sep 29, 2020··Adam M DubisMariya Moosajee

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Methods Mentioned

BETA
Scanning
imaging techniques

Software Mentioned

ImageJ
AngioVue Analytics
SSADA
AOSLO
SPSS

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