Retinal cavitations in macular telangiectasia type 2 (MacTel): longitudinal structure-function correlations.

The British Journal of Ophthalmology
Cindy X CaiGlenn J Jaffe

Abstract

To quantify retinal cavitation size over time in macular telangiectasia type 2 (MacTel) and to correlate changes with visual acuity and area of ellipsoid zone loss. Optical coherence tomography (OCT) macula volume scans from sham eyes included in a prospective, phase II clinical trial of human ciliary neutrophic factor for MacTel at baseline, 1 year and 2 years of follow-up were analysed. Cavitations were segmented by two independent readers. Total cavitation volume was compared with area of ellipsoid zone loss and best-corrected visual acuity (BCVA). Fifty-one eyes from 51 unique patients (mean age 62 years, range 45-79 years) were included. Intraclass correlation between readers for cavitation volume was excellent (>0.99). Average cavitation volume was 0.0109 mm3, 0.0113 mm3 and 0.0124 mm3 at baseline, 1 year and 2 years, respectively. The average rate of cavitation volume change was +0.0039 mm3/year. 10 eyes (20%) had a significant change in cavitation volume during the study (3 decreased, 7 increased). Eyes with increased cavitation volume had worse BCVA compared with eyes with no change/decreased cavitation volume (71.5 vs 76.1 ETDRS letters, respectively). Cavitation volume was negatively correlated to BCVA (r=-0.37) but ...Continue Reading

References

May 1, 1982·Archives of Ophthalmology·J D Gass, R T Oyakawa
Apr 12, 2006·Archives of Ophthalmology·Lawrence A YannuzziBarbara Blodi
Apr 29, 2008·Investigative Ophthalmology & Visual Science·Daniel BarthelmesMark C Gillies
May 21, 2010·Physical Review Letters·A M Labin, E N Ribak
Aug 4, 2010·Ophthalmology·Michael B PownerMarcus Fruttiger
Oct 25, 2012·Investigative Ophthalmology & Visual Science·Ferenc B SalloUNKNOWN MacTel Study Group
Feb 27, 2013·Glia·Andreas Reichenbach, Andreas Bringmann
Jun 19, 2013·Ophthalmology·Michael B PownerMarcus Fruttiger
Sep 14, 2013·European Journal of Ophthalmology·Gabriel CoscasEric SouÏed
Dec 1, 2015·Retina·Peter Charbel IssaTos T J M Berendschot
Oct 4, 2017·Investigative Ophthalmology & Visual Science·Dibyendu MukherjeeUNKNOWN MacTel Study Group
Oct 8, 2018·Ophthalmology·Emily Y ChewUNKNOWN Macular Telangiectasia Type 2-Phase 2 CNTF Research Group

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