Retinal Cell Degeneration in Animal Models

International Journal of Molecular Sciences
Masayuki NiwaAkira Hara

Abstract

The aim of this review is to provide an overview of various retinal cell degeneration models in animal induced by chemicals (N-methyl-D-aspartate- and CoCl2-induced), autoimmune (experimental autoimmune encephalomyelitis), mechanical stress (optic nerve crush-induced, light-induced) and ischemia (transient retinal ischemia-induced). The target regions, pathology and proposed mechanism of each model are described in a comparative fashion. Animal models of retinal cell degeneration provide insight into the underlying mechanisms of the disease, and will facilitate the development of novel effective therapeutic drugs to treat retinal cell damage.

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Citations

Feb 15, 2017·Oxidative Medicine and Cellular Longevity·Tomomi MasudaHideaki Hara
Mar 21, 2017·Journal of Pharmacological Sciences·Yukimichi NakanoHideaki Hara
Mar 11, 2020·International Journal of Molecular Sciences·Rooban B NahomiRam H Nagaraj
Jul 8, 2019·Molecular Neurobiology·Chithra D PalaniS Priya Narayanan
Jun 18, 2020·Frontiers in Cell and Developmental Biology·Julia Eymann, Nicolas Di-Poï
May 28, 2020·Cells·Lucia G Le RouxDawid Schellingerhout
Jul 3, 2021·Biology·Mariela Subileau, Daniel Vittet
Apr 30, 2021·European Surgical Research. Europäische Chirurgische Forschung. Recherches Chirurgicales Européennes·Juan San Cristóbal EpalzaBorja Herrero de la Parte

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Methods Mentioned

BETA
transgenic
nucleotide exchange
pharmacotherapy

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