PMID: 3384019May 1, 1988Paper

Retinal damage by constant light in chimaeric mice: implications for the protective role of melanin

Experimental Eye Research
S Sanyal, G H Zeilmaker

Abstract

Adult chimaeric mice, containing varying proportions of albino and pigmented cells in their ocular tissues, were exposed to constant light for 5 weeks and the distribution of the surviving rod perikarya in the retina and of the pigmented cells in various eye tissues were compared. In chimaeras which were mostly albino, the retinal lesion was similar to that in pure strain albino mice; in chimaeras with relatively more pigmented cells in their ocular tissues, the retina was unaffected as in fully pigmented mice. In chimaeras with amounts of pigmented cells in their ocular tissues varying between these two ends, lesions of intermediate degrees could be observed. Surviving rod cells in such chimaeric retinas were always found in regions adjoining the periphery. The location of the rod perikarya in such regions did not show an exact correlation with that of the overlying pigmented cells but regions of the outer nuclear layer with surviving rod perikarya were generally located in the half or quarter of the retina in which the overlying pigment epithelium also contained more pigmented cells than in the other regions. The proportions of the surviving photoreceptor cells varied between such chimaeras. The lesion appeared to be less ext...Continue Reading

References

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Citations

Jan 1, 1992·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·J RamirezM Wenzel
Dec 1, 1995·Free Radical Biology & Medicine·R DunfordT G Truscott
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Apr 27, 2007·Investigative Ophthalmology & Visual Science·Sanny ChanJeannie Chen
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Jan 1, 2013·Experimental Eye Research·Shi Bai, Christian T Sheline
Jan 18, 2015·Free Radical Biology & Medicine·G ElachouriT Léveillard
Sep 18, 2008·Current Eye Research·S Nusinowitz, D Sarraf
Apr 12, 2018·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Ayyad Z KhanJon R Eidet
Aug 8, 2013·The Cochrane Database of Systematic Reviews·Eliane C JorgeRegina P El Dib
Sep 26, 2019·Scientific Reports·Laura HellinenMika Reinisalo
Apr 20, 2019·Fish Physiology and Biochemistry·Qi LiuYing Liu

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