Retinal detachment and proliferative vitreoretinopathy: ophthalmic artery blood velocities, intraocular pressure, and endothelin-1

Retina
M Roldán-PallarésR Fernández-Durango

Abstract

To analyze if endothelin-1 (ET-1) may have an effect on ophthalmic artery (OA) blood flow velocities and intraocular pressure (IOP) in retinal detachment (RD). Using radioimmunoassay, immunoreactive (IR) ET-1 levels were tested in both plasma and subretinal fluid (SRF) specimens from patients with RD, while only plasma specimens from normal (healthy) subjects were tested. OA Doppler sonography parameters and IOP were measured in eyes with RD, with and without proliferative vitreoretinopathy (PVR), their respective healthy fellow eyes, and normal eyes. RD eyes had lower OA peak systolic velocity (PSV) and end diastolic velocity (EDV), higher resistivity index (RI), lower IOP, and higher plasma IR ET-1 levels than normal eyes (P < 0.0001). Eyes with PVR had lower OA PSV and EDV, higher RI, lower IOP, higher plasma IR ET-1 levels, and higher SRF IR ET-1 than eyes without PVR (P < 0.0001). A statistically significant linear correlation was found among OA parameters, IOP, and SRF IR ET-1 measurements. Decreased OA blood flow velocities may explain lower IOP found in RD patients, and ET-1 levels may be responsible for both measurements.

References

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Citations

Sep 26, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Manuela Roldán-PallarèsRaquel Fernández-Durango
Apr 14, 2010·Survey of Ophthalmology·Galina Dimitrova, Satoshi Kato
Dec 17, 2009·Regulatory Peptides·E M VingoloC Letizia
Nov 1, 2011·The American Journal of Pathology·Steven PennockAndrius Kazlauskas
Mar 21, 2016·Survey of Ophthalmology·Dean LoporchioNeelakshi Bhagat
May 3, 2015·Journal français d'ophtalmologie·M-G Barcatali, E Denion
Aug 21, 2012·The American Journal of Pathology·Hetian LeiAndrius Kazlauskas

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