PMID: 18401297Apr 11, 2008Paper

Retinal detachment: visual acuity and subretinal immunoreactive endothelin-1

Journal français d'ophtalmologie
Manuela Roldán-PallarésRaquel Fernández-Durango

Abstract

To analyze whether subretinal (SRF) endothelin-1 (ET-1) - a vasoactive, mitogenic, and pro-apoptotic peptide - levels are related to visual acuity (VA) in rhegmatogenous retinal detachment (RD). Sixty-six healthy patients between 42 and 70 years of age with unilateral RD, all candidates for scleral buckling surgery (PVR<C3) as a first and single surgical procedure, were prospectively selected. Using radioimmunoassay, immunoreactive ET-1 (IR-ET-1) was tested in both plasma and subretinal fluid (SRF) of these retinal detachment (RD) patients. Best-corrected Snellen VA was considered before surgery (preoperative) and 8 months after surgery (postoperative). Pearson correlations were made between IR-ET-1 levels (in plasma and SRF) and VA (preoperative, postoperative, and postoperative minus preoperative difference). Mean IR-ET-1 values were plasma, 2.91+/-0.44 pg/ml, and SRF, 10.71+/-7.95 pg/ml. Mean VA values were preoperative VA, 0.31+/-0.16; postoperative VA, 0.66+/-0.29; and VA difference, 0.35+/-0.18. Plasma IR-ET-1 showed significant (p<0.0001) negative linear correlations with preoperative VA (r=-0.52), postoperative VA (r=-0.69), and VA difference (r=-0.65). SRF IR-ET-1 showed significant (p<0.0001) negative linear correlati...Continue Reading

References

Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·M W MacCumberS H Snyder
Sep 1, 1994·Archives of Ophthalmology·M W MacCumber, S A D'Anna
Feb 1, 1965·Archives of Ophthalmology·H A LINCOFFJ MCLEAN

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Citations

Jan 22, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Manuela Roldán-PallarésCarmen Bravo-Llatas
Sep 26, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Manuela Roldán-PallarèsRaquel Fernández-Durango
Dec 17, 2009·Regulatory Peptides·E M VingoloC Letizia
Jan 1, 2010·Journal of Ophthalmology·Serena Salvatore, Enzo Maria Vingolo
Dec 19, 2018·Acta Ophthalmologica·Justus G GarwegChristoph Tappeiner
Feb 9, 2012·Journal of Periodontology·L Susan TaichmanMaryfran Sowers
Feb 23, 2020·Investigative Ophthalmology & Visual Science·Eun Hee HongMincheol Seong
Apr 4, 2019·PloS One·Souska ZandiJustus G Garweg

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