Retinal Differential Light Sensitivity Variation Across the Macula in Healthy Subjects: Importance of Cone Separation and Loci Eccentricity.

Translational Vision Science & Technology
Danuta M SampsonFred K Chen

Abstract

Microperimetry measures differential light sensitivity (DLS) at specific retinal locations. The aim of this study is to examine the variation in DLS across the macula and the contribution to this variation of cone distribution metrics and retinal eccentricity. Forty healthy eyes of 40 subjects were examined by microperimetry (MAIA) and adaptive optics imaging (rtx1). Retinal DLS was measured using the grid patterns: foveal (2°-3°), macular (3°-7°), and meridional (2°-8° on horizontal and vertical meridians). Cone density (CD), distribution regularity, and intercone distance (ICD) were calculated at the respective test loci coordinates. Linear mixed-effects regression was used to examine the association between cone distribution metrics and loci eccentricity, and retinal DLS. An eccentricity-dependent reduction in DLS was observed on all MAIA grids, which was greatest at the foveal-parafoveal junction (2°-3°) (-0.58 dB per degree, 95% confidence interval [CI]; -0.91 to -0.24 dB, P < 0.01). Retinal DLS across the meridional grid changed significantly with each 1000 cells/deg2 change in CD (0.85 dB, 95% CI; 0.10 to 1.61 dB, P = 0.03), but not with each arcmin change in ICD (1.36 dB, 95% CI; -2.93 to 0.20 dB, P = 0.09). We demonstr...Continue Reading

References

Nov 1, 1985·The British Journal of Ophthalmology·N A Jacobs, I H Patterson
Oct 1, 1965·Vision Research·V D Glezer
Jun 1, 1994·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·A G BennettD F Edgar
Jul 31, 1998·American Journal of Ophthalmology·K RohrschneiderH E Völcker
Apr 2, 1999·The European Journal of Neuroscience·L Galli-RestaB E Reese
Apr 8, 2003·Journal of Vision·Austin Roorda, David R Williams
Apr 13, 2007·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Rigmor C BaraasMaureen Neitz
Jun 27, 2007·Investigative Ophthalmology & Visual Science·Jacque L DuncanAustin Roorda
Jun 20, 2008·Vision Research·Dingcai CaoAndrew J Zele
Oct 14, 2008·Ophthalmic Research·Vinay A Shah, K V Chalam
Oct 28, 2008·Investigative Ophthalmology & Visual Science·Jessica I W MorganDavid R Williams
Dec 22, 2009·Nature Neuroscience·Ethan A Rossi, Austin Roorda
May 12, 2011·Biomedical Optics Express·Elise W DeesRigmor C Baraas
Jul 5, 2011·Investigative Ophthalmology & Visual Science·Hongxin SongStephen A Burns
Feb 15, 2012·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Andrew J ZeleBeatrix Feigl
Mar 27, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·William S TutenAustin Roorda
Apr 17, 2012·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Robert GarriochJoseph Carroll
Jan 10, 2013·Investigative Ophthalmology & Visual Science·Reema SyedJacque L Duncan
Mar 30, 2013·Retina·Marco LombardoSebastiano Serrao
Apr 5, 2013·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Marco LombardoGiuseppe Lombardo
Jun 14, 2013·Biomedical Optics Express·Stephanie J ChiuSina Farsiu
Apr 15, 2014·The British Journal of Ophthalmology·Manickam Nick MuthiahLyndon da Cruz
Jan 15, 2015·Journal of Vision·Sieu K Khuu, Michael Kalloniatis
Jul 15, 2015·BioMed Research International·Dabir SupriyaBharath Hegde
Dec 30, 2015·Biomedical Optics Express·Danuta M BukowskaFred K Chen
Jun 9, 2016·Investigative Ophthalmology & Visual Science·Robert F CooperJoseph Carroll
Oct 30, 2016·Data in Brief·Andrew T AstleJonathan Denniss
Jun 6, 2017·Survey of Ophthalmology·Nicola K CasselsJennifer H Acton
Oct 31, 2017·Investigative Ophthalmology & Visual Science·Jasleen K JollyRobert E MacLaren
Oct 8, 2018·Ophthalmology·Emily Y ChewUNKNOWN Macular Telangiectasia Type 2-Phase 2 CNTF Research Group
Feb 10, 2019·Proceedings of the National Academy of Sciences of the United States of America·MiYoung Kwon, Rong Liu

❮ Previous
Next ❯

Software Mentioned

Excel
VoronoiLimit
ImageJ
Statistical Package for Social Sciences ( SPSS
MAIA
Matlab
R
nlme

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.