Retinal Endovascular Surgery with Tissue Plasminogen Activator Injection for Central Retinal Artery Occlusion

Case Reports in Ophthalmology
Yuta TakataAtsushi Hayashi

Abstract

To report 2 cases of central retinal artery occlusion (CRAO) who underwent retinal endovascular surgery with injection of tissue plasminogen activator (tPA) into the retinal artery and showed a remarkable improvement in visual acuity and retinal circulation. Standard 25-G vitrectomy was performed under local anesthesia. Simultaneously, tPA (80,000 units/mL) solution was injected into the retinal artery of the optic disc for 2-3 min using a microneedle. Changes in visual acuity, fundus photography, optical coherence tomography (OCT), fluorescein angiography, and laser speckle flowgraphy (LSFG) results were examined. Both cases could be treated within 12 h after the onset of CRAO. Case 1 was a 47-year-old woman. Her visual acuity improved from counting fingers before operation to 0.08 logMAR 1 month after the surgery. However, thinning of the retina at the macula was observed by OCT. Case 2 was a 70-year-old man. His visual acuity improved from counting fingers to 0.1 logMAR 2 months after the surgery. Both fluorescein angiography and LSFG showed improvement in retinal circulation after the surgery in case 2. Retinal endovascular surgery with injection of tPA into the retinal artery was feasible and may be a way to improve visual...Continue Reading

References

Dec 1, 1982·Ophthalmology·J Arruga, M D Sanders
Apr 27, 2004·Experimental Eye Research·Sohan Singh HayrehAshish Sanon
Sep 6, 2005·Retina·Richard M Feist, Tracy L Emond
Jul 21, 2006·The British Journal of Ophthalmology·J García-ArumíB Corcostegui
Sep 4, 2009·Acta Ophthalmologica·Tetsuya SugiyamaSelim Orgul
Jun 15, 2013·JAMA Ophthalmology·Kazuaki KadonosonoShiro Amano
Sep 7, 2016·Investigative Ophthalmology & Visual Science·Kwan Hyuk ChoSe Joon Woo
Aug 15, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Masaaki IshidaAtsushi Hayashi
Jan 24, 2018·Scientific Reports·Kazuaki KadonosonoEiichi Uchio

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Citations

Nov 9, 2020·Japanese Journal of Ophthalmology·Kazuaki KadonosonoEugene de Juan
Jan 30, 2021·Case Reports in Ophthalmological Medicine·A Altun
May 20, 2021·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Brian Mac GroryWuwei Feng

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