Retinal function in rabbits does not improve 4-5 months after terminating treatment with vigabatrin.

Documenta Ophthalmologica. Advances in Ophthalmology
Ulrika KjellströmVesna Ponjavic

Abstract

We have previously reported changes in retinal function and histopathology in rabbits treated with vigabatrin. The purpose of the present study was to evaluate retinal function and histopathology of retina in rabbits 4-5 months after terminating vigabatrin medication. Five rabbits were treated with a daily per oral dose of vigabatrin during 12-13 months. After terminating treatment an observation period of 4-5 months followed. Six rabbits receiving water served as controls. Standardized full-field electroretinograms were performed every 6-8 weeks, using a Burian-Allen bipolar contact lens. After 18 months the rabbits were sacrificed and the morphology of the sectioned retina was studied. The antibodies used for staining were GABA, GFAP, GAD, and vimentin. After 12-13 months of treatment the full-field ERG was reduced in all rabbits treated with vigabatrin. There was a statistically significant difference in the dark adapted cone b-wave amplitude between treated animals and controls (Wilcoxon signed-rank test, p = 0.043). This difference was consistent also 4-5 months after terminating treatment. Immunohistology of the sectioned retina demonstrated no significant difference in immunoreactivity between treated animals and control...Continue Reading

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Citations

May 5, 2009·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ulrika KjellströmVesna Ponjavic
Nov 11, 2008·Documenta Ophthalmologica. Advances in Ophthalmology·Ido Perlman
Jun 19, 2012·American Journal of Ophthalmology·Tamara L BerezinaRobert D Fechtner
Mar 13, 2015·Documenta Ophthalmologica. Advances in Ophthalmology·James D AkulaAnne B Fulton
Jun 1, 2013·Journal of Applied Physiology·Aaron A HallRichard T Mahon

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