Retinal ganglion cell axon sorting at the optic chiasm requires dystroglycan

Developmental Biology
Reena Clements, Kevin M Wright

Abstract

In the developing visual system, retinal ganglion cell (RGC) axons project from the retina to several distal retinorecipient regions in the brain. Several molecules have been implicated in guiding RGC axons in vivo, but the role of extracellular matrix molecules in this process remains poorly understood. Dystroglycan is a laminin-binding transmembrane protein important for formation and maintenance of the extracellular matrix and basement membranes and has previously been implicated in axon guidance in the developing spinal cord. Using two genetic models of functional dystroglycan loss, we show that dystroglycan is necessary for correct sorting of contralateral and ipsilateral RGC axons at the optic chiasm. Mis-sorted axons still target retinorecipient brain regions and persist in adult mice, even after axon pruning is complete. Our results highlight the importance of the extracellular matrix for axon sorting at an intermediate choice point in the developing visual circuit.

Citations

Feb 14, 2019·ELife·L Bailey LindenmaierKevin M Wright
Jun 7, 2019·Annals of the New York Academy of Sciences·Rory K MorganAmit Mogha
May 13, 2020·Annual Review of Vision Science·Carol Mason, Nefeli Slavi
Aug 22, 2020·Current Opinion in Neurobiology·Joelle M Dorskind, Alex L Kolodkin
May 18, 2021·Cells & Development·Camila Davison, Flavio R Zolessi
Oct 17, 2021·Proceedings of the National Academy of Sciences of the United States of America·Jianmin SuMichael A Fox

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