PMID: 2487657Jan 1, 1989Paper

Retinal ganglion cell death induced by unilateral tectal ablation in Xenopus

Visual Neuroscience
C StraznickyP Tóth

Abstract

The survival of retinal ganglion cells (GCs) in the left eye was studied on retinal wholemounts from 2-33 weeks after the surgical removal of the right tectum in juvenile Xenopus. Two to five weeks after tectal removal, about 76% of neurons of the retinal ganglion cell (GC) layer showed signs of retrograde degeneration: swelling of their somata and chromatolysis. Neurons that were not affected by the operation were taken to be either displaced amacrine cells (DAs) or GCs not projecting to the tectum. A portion of GCs showing retrograde degeneration became pyknotic and died within the period of 2-16 weeks after operation. Counts of surviving GCs 20-33 weeks after tectal removal amounted to about 55% of the corresponding neuron number in the right intact retina of the same animal. No discernible GC loss was observed in animals where only the optic fibers were cut at their entry point to the tectum indicating that axotomy alone, followed by rapid regrowth to the target, does not adversely influence the survival of GCs. In long-surviving animals, the left optic nerve was exposed to cobaltic-lysine complex and the position of filled optic axons within the brain determined. Optic axons whose tectal target had been removed were seen t...Continue Reading

References

Mar 9, 1979·Experimental Brain Research·V H Perry, A Cowey
Jul 1, 1979·Stain Technology·F Gallyas
Oct 1, 1975·The Journal of Comparative Neurology·W Franklin Hughes, A La Velle
Jun 15, 1985·The Journal of Comparative Neurology·M F Humphrey, L D Beazley
Mar 1, 1988·Trends in Neurosciences·H Wässle
Jan 1, 1988·Anatomy and Embryology·C Straznicky, I T Straznicky
Apr 22, 1987·The Journal of Comparative Neurology·R V Stirling, E G Merrill
Dec 15, 1987·The Journal of Comparative Neurology·B D Frank, J G Hollyfield
Apr 22, 1986·The Journal of Comparative Neurology·D R SengelaubB L Finlay
Apr 8, 1985·The Journal of Comparative Neurology·N M MontgomeryA M Grigonis
Mar 20, 1983·The Journal of Comparative Neurology·G LázárE Kicliter
Dec 20, 1981·The Journal of Comparative Neurology·N MontgomeryL Bengston
Jun 24, 1982·Nature·V H Perry, R Linden
Jul 1, 1960·The Journal of General Physiology·H R MATURANAW H PITTS

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