Retinal Ganglion Cell Layer Analysis by Optical Coherence Tomography in Toxic and Nutritional Optic Neuropathy

Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society
Luisa Margarida Cabral VieiraJoão Paulo Pedrosa Branco da Cunha

Abstract

To analyze the retinal ganglion cell layer (RGL) by optical coherence tomography (OCT) in toxic and nutritional optic neuropathy and to correlate its thickness and volume with functional damage. We conducted an observational cross-sectional study in healthy subjects and in patients with toxic optic neuropathy observed in the Neuro-Ophthalmology Department of Central Lisbon Hospital Center. Complete ophthalmologic examination, OCT (Heidelberg Spectralis), and automated static perimetry were performed. Thickness and macular volume of RGL layer and inner plexiform layer were measured after manual segmentation. The study included 16 eyes of 12 healthy subjects and 16 eyes of 8 patients with toxic and nutritional optic neuropathy. Age and gender did not differ between the 2 groups. Ethambutol was the cause of toxic optic neuropathy in 4 patients and nutritional factors (tobacco-alcohol) in 4 patients. A statistically significant decrease in thickness and volume of RGL, in all quadrants at 2 and 3 mm, was detected in individuals with optic neuropathy compared with controls (P < 0.01). A positive correlation between RGL thickness and mean deviation (MD) and between RGL volume and MD was detected (P < 0.05). There was a negative correl...Continue Reading

References

Nov 7, 2003·Mayo Clinic Proceedings·Alex MelamudMichael S Lee
Sep 1, 2004·Ophthalmology Clinics of North America·John B Kerrison
Nov 27, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Christopher I ZoumalanAlfredo A Sadun
Aug 21, 2007·Journal of the Neurological Sciences·C OrssaudJ L Dufier
Apr 28, 2009·European Journal of Ophthalmology·Ungsoo Kim, Jeong-Min Hwang
Dec 24, 2009·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Yong-Kyu Kim, Jeong-Min Hwang
Aug 11, 2010·Seminars in Ophthalmology·Carlos E Mendoza-SantiestebanSergio Vidal Casali
Oct 19, 2011·Brain : a Journal of Neurology·Stephanie B SycPeter A Calabresi
Dec 14, 2011·Canadian Journal of Ophthalmology. Journal Canadien D'ophtalmologie·Pilar A M MorenoTiago Santos Prata
Dec 14, 2011·Archives of Ophthalmology·Ali S RazaDonald C Hood
Aug 21, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Penpe Gul FiratCemil Colak
Sep 8, 2012·Investigative Ophthalmology & Visual Science·Junzo KinoshitaMitsuya Yasuda
Sep 15, 2012·Investigative Ophthalmology & Visual Science·Kohei TakayamaNagahisa Yoshimura
May 25, 2013·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·S Bianchi MarzoliD D'Amico
Sep 5, 2013·Ophthalmology·Hideo AkiyamaShoji Kishi
Oct 9, 2013·Current Opinion in Ophthalmology·Ugur E Altiparmak
Jun 8, 2014·American Journal of Ophthalmology·Piero BarboniValerio Carelli

❮ Previous
Next ❯

Citations

May 24, 2016·American Journal of Ophthalmology·Kwan Hyuk ChoKyu Hyung Park
Dec 19, 2016·Revista Portuguesa De Pneumologia·L FigueiraR Duarte
Mar 8, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·John J Chen
May 20, 2020·Investigative Ophthalmology & Visual Science·Sharon Y L ChuaUNKNOWN UK Biobank Eye and Vision Consortium
Sep 4, 2020·Nutrients·Matilde RodaCostantino Schiavi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antitubercular Agents (ASM)

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.

Antitubercular Agents

Antitubercular agents are pharmacologic agents for treatment of tuberculosis. Discover the latest research on antitubercular agents here.