Retinal imaging including optical coherence tomography angiography for detecting active choroidal neovascularization in pseudoxanthoma elasticum

Clinical & Experimental Ophthalmology
Johannes BirtelPeter Charbel Issa

Abstract

The diagnostic accuracy of different retinal imaging modalities to detect active choroidal neovascularization (CNV) in pseudoxanthoma elasticum (PXE) is essential to enable a correct diagnosis but is currently poorly understood. Optical coherence tomography (OCT), fluorescein angiography (FA) and OCT angiography (OCT-A) are employed in daily practice, but a systematic comparison of these imaging techniques is lacking. Retrospective, observational study. Twenty patients (31 eyes) with PXE. OCT, FA and OCT-A imaging was performed in each eye and graded separately by independent readers. Diagnostic accuracy, sensitivity and specificity to detect CNV-activity of each modality and longitudinal change of CNV size measured by OCT-A. OCT showed the highest diagnostic accuracy (kappa = 0.57) in comparison to OCT-A or FA (kappa = 0.39 and 0.37, respectively). OCT-A, OCT and FA showed a diagnostic sensitivity of 0.9, 0.85 and 0.6, and a diagnostic specificity of 0.45, 0.72 and 0.82, respectively. Evaluation of longitudinal OCT recordings (24 eyes) resulted in optimal sensitivity and specificity (kappa = 1.0). Although median CNV size assessed using OCT-A remained stable on longitudinal measures of seven eyes, two eyes showed a distinct in...Continue Reading

References

Aug 1, 1966·Psychological Reports·J J Bartko
Sep 12, 2003·American Journal of Ophthalmology·Stefan MennelCarsten H Meyer
Nov 21, 2007·Health Technology Assessment : HTA·A W S RutjesP M M Bossuyt
Oct 23, 2010·Retina·Sandrine A ZweifelRichard F Spaide
May 5, 2012·Ophthalmology·UNKNOWN Comparison of Age-related Macular Degeneration Treatments Trials (CATT) Research GroupFrederick L Ferris
Nov 2, 2012·Retina·Satoko NakagawaNagahisa Yoshimura
Dec 19, 2012·Frontiers in Genetics·Olivier Le SauxChristopher N Brampton
Apr 12, 2013·Frontiers in Genetics·Martin GliemPeter Charbel Issa
Jul 19, 2014·American Journal of Ophthalmology·Jesse J JungK Bailey Freund
Oct 8, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Mariana R ThorellPhilip J Rosenfeld
Nov 26, 2014·Ophthalmic Surgery, Lasers & Imaging Retina·Eric MoultJames G Fujimoto
Mar 22, 2015·Ophthalmology·Talisa E de CarloNadia K Waheed
Apr 22, 2015·Proceedings of the National Academy of Sciences of the United States of America·Yali JiaDavid Huang
Jul 7, 2015·Ophthalmology·Alex S WilloughbyUNKNOWN Comparison of Age-Related Macular Degeneration Treatments Trials Research Group
Jul 15, 2015·American Journal of Ophthalmology·Laura KuehleweinDavid Sarraf
Jun 29, 2016·American Journal of Ophthalmology·Kunal K DansinganiK Bailey Freund
Jul 14, 2016·Investigative Ophthalmology & Visual Science·Maiko InoueUNKNOWN COFT-1 Study Group
Apr 15, 2015·International Journal of Retina and Vitreous·Talisa E de CarloJay S Duker
Aug 7, 2015·International Journal of Retina and Vitreous·Orly Gal-OrK Bailey Freund
Nov 30, 2016·Investigative Ophthalmology & Visual Science·Moritz LindnerMonika Fleckenstein
Dec 4, 2016·The British Journal of Ophthalmology·Mehrdad MalihiSteven T Bailey
Aug 2, 2017·Progress in Retinal and Eye Research·Amir H KashaniRuikang K Wang
Oct 24, 2017·Ophthalmology Retina·Ambar FaridiSteven T Bailey

❮ Previous
Next ❯

Citations

May 24, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Vittoria MurroFabrizio Giansanti
Jun 27, 2020·Indian Journal of Ophthalmology·Kaushik MuraliB Kumari
Dec 22, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Martin GliemPeter Charbel Issa
Oct 20, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·João Pedro MarquesRufino Silva
Mar 22, 2021·Orphanet Journal of Rare Diseases·Graeme C BlackUNKNOWN ERN-EYE study group
Mar 31, 2021·Klinische Monatsblätter für Augenheilkunde·Johannes BirtelPeter Charbel Issa
May 26, 2020·Klinische Monatsblätter für Augenheilkunde·Mustafa Cumhur VardarliKarl Rudolf Berret

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.