Retinal layer location of increased retinal thickness in eyes with subclinical and clinical macular edema in diabetes type 2

Ophthalmic Research
Francesco BandelloEVICR.net

Abstract

To identify the retinal layer predominantly affected in eyes with subclinical and clinical macular edema in diabetes type 2. A cohort of 194 type 2 diabetic eyes/patients with mild nonproliferative diabetic retinopathy (ETDRS levels 20/35) were examined with Cirrus spectral-domain optical coherence tomography (OCT) at the baseline visit (ClinicalTrials.gov identifier: NCT01145599). Automated segmentation of the retinal layers of the eyes with subclinical and clinical macular edema was compared with a sample of 31 eyes from diabetic patients with normal OCT and an age-matched control group of 58 healthy eyes. From the 194 eyes in the study, 62 had subclinical macular edema and 12 had clinical macular edema. The highest increases in retinal thickness (RT) were found in the inner nuclear layer (INL; 33.6% in subclinical macular edema and 81.8% in clinical macular edema). Increases were also found in the neighboring layers. Thinning of the retina was registered in the retinal nerve fiber, ganglion cells and inner plexiform layers in the diabetic eyes without macular edema. The increase in RT occurring in diabetic eyes with macular edema is predominantly located in the INL but extends to neighboring retinal layers indicating that it...Continue Reading

Citations

Mar 18, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Teruyo KidaTsunehiko Ikeda
Jun 30, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Hyung Bin LimJung Yeul Kim
Apr 28, 2018·The British Journal of Ophthalmology·Rajeev K R PappuruJosé Cunha-Vaz
Mar 18, 2020·Investigative Ophthalmology & Visual Science·Inês P MarquesJosé Cunha-Vaz
Apr 2, 2020·International Journal of Molecular Sciences·Shou OosukaTsunehiko Ikeda
Apr 17, 2020·PloS One·Jacoba A van de KreekeFrank D Verbraak
Jul 1, 2017·Diabetes·Ana Rita SantosUNKNOWN European Consortium for the Early Treatment of Diabetic Retinopathy (EUROCONDOR)
Mar 25, 2018·Microscopy Research and Technique·Xue-Huan LiuZhen-Chang Wang
Nov 21, 2018·Ophthalmic Surgery, Lasers & Imaging Retina·Stela VujosevicEdoardo Midena
Oct 31, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Sonja G KarstUrsula Schmidt-Erfurth
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Jul 25, 2021·Journal of Clinical Medicine·Luisa FrizzieroEdoardo Midena
Apr 24, 2019·Ophthalmic Research·Ana Rita SantosJosé Cunha-Vaz

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