Retinal microglia signaling affects Müller cell behavior in the zebrafish following laser injury induction

Glia
Federica M ConederaVolker Enzmann

Abstract

Microglia are the resident tissue macrophages of the central nervous system including the retina. Under pathophysiological conditions, microglia can signal to Müller cells, the major glial component of the retina, affecting their morphological, molecular, and functional responses. Microglia-Müller cell interactions appear to be bidirectional shaping the overall injury response in the retina. Hence, microglia and Müller cell responses to disease and injury have been ascribed both positive and negative outcomes. However, Müller cell reactivity and survival in the absence of immune cells after injury have not been investigated in detail in adult zebrafish. Here, we develop a model of focal retinal injury combined with pharmacological treatments for immune cell depletion in zebrafish. The retinal injury was induced by a diode laser to damage photoreceptors. Two pharmacological treatments were used to deplete either macrophage-microglia (PLX3397) or selectively eliminate peripheral macrophages (clodronate liposomes). We show that PLX3397 treatment hinders retinal regeneration in zebrafish, which is reversed by microglial repopulation. On the other hand, selective macrophage elimination did not affect the kinetics of retinal regenera...Continue Reading

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Citations

Apr 29, 2020·Annual Review of Vision Science·Manuela LahnePeter F Hitchcock
Sep 15, 2020·Frontiers in Cell and Developmental Biology·Larissa IkelleMuna I Naash
Jun 18, 2020·Frontiers in Cell and Developmental Biology·Julia Eymann, Nicolas Di-Poï
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Sep 5, 2021·Archivos De La Sociedad Española De Oftalmología·Z S Ulhaq, G V Soraya
Oct 2, 2021·Molecular Neurodegeneration·Federica Maria ConederaVolker Enzmann

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