Retinal neovascularization after intravitreal fibroblast injection

American Journal of Ophthalmology
Y TanoR Machemer

Abstract

We have developed a new model of retinal neovascularization in the rabbit. After intravitreal autotransplantation of 250,000 tissue-cultured skin fibroblasts, we observed strand formation in the midvitreous cavity. These strands grew toward the vascularized part of the retina and attached to it. Once the attachment was established, retinal neovascularization began with growth of vessels along the fibrous strand. After three months, this retinal neovascularization regressed. The presence of immature capillaries was confirmed by electron microscopic examination. Of 43 eyes, 31 (72%) developed neovascularization.

References

Jun 1, 1975·Experimental Eye Research·A M HamiltonJ A Bowbyes
Jul 1, 1981·American Journal of Ophthalmology·Y TanoR Machemer
Feb 1, 1964·The British Journal of Ophthalmology·G IMRE

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Citations

May 1, 1982·American Journal of Ophthalmology·D M FastenbergS J Ryan
Jul 17, 2014·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Emmerson BadaroEduardo Buchele Rodrigues
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Apr 18, 2009·Seminars in Ophthalmology·Sandra R MontezumaJoan W Miller

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