Retinal nerve fiber bundle tracing and analysis in human eye by polarization sensitive OCT

Biomedical Optics Express
Mitsuro SugitaChristoph K Hitzenberger

Abstract

We present a new semi-automatic processing method for retinal nerve fiber bundle tracing based on polarization sensitive optical coherence tomography (PS-OCT) data sets. The method for tracing is based on a nerve fiber orientation map that covers the fovea and optic nerve head (ONH) regions. In order to generate the orientation map, two types of information are used: optic axis orientation based on polarization data, and complementary information obtained from nerve fiber layer (NFL) local thickness variation to reveal fiber bundle structures around the fovea. The corresponding two orientation maps are fused into a combined fiber orientation map. En face maps of NFL retardation, thickness, and unit-depth-retardation (UDR, equivalent to birefringence) are transformed into "along-trace" maps by using the obtained traces of the nerve fiber bundles. The method is demonstrated in the eyes of healthy volunteers, and as an example of further analyses utilizing this method, maps illustrating the gradients of NFL retardation, thickness, and UDR are demonstrated.

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Citations

Jan 29, 2016·Biomedical Optics Express·Xiang-Run HuangJianzhong Qiao
Apr 29, 2016·Journal of Biomedical Optics·Valery V Tuchin
Jul 1, 2017·Biomedical Optics Express·Florian BeerChristoph K Hitzenberger
May 31, 2019·Biomedical Optics Express·R A Leitgeb
Oct 27, 2020·Translational Vision Science & Technology·Nomdo M Jansonius, Ulrich Schiefer
Oct 29, 2020·Translational Vision Science & Technology·David A MillerHao F Zhang
Apr 20, 2021·Investigative Ophthalmology & Visual Science·Andreas PollreiszUrsula Schmidt-Erfurth
Aug 31, 2021·Biomedical Optics Express·Alice R MotschiChristoph K Hitzenberger
Sep 24, 2021·Light, Science & Applications·Chao HeMartin J Booth

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