Retinal nerve fiber layer and macular thickness in adolescents with epilepsy treated with valproate and carbamazepine

Epilepsia
L LobefaloA Verrotti

Abstract

To evaluate retinal nerve retinal nerve fiber layer (RNFL) and macular thickness by using optical coherence tomography (OCT) in epileptic adolescents before and during monotherapy with valproic acid (VPA) and carbamazepine (CBZ). We examined prospectively 45 epilepsy patients with partial and generalized epilepsy. The patients were evaluated before the beginning of therapy and after 1 year of VPA or CBZ monotherapy. Forty-five untreated healthy controls were evaluated at baseline and after 1 year. At the beginning of the study, the two groups of patients showed RNFL and macular thickness measurements similar to control values. At the end of the follow-up, the data of the three groups were similar to baseline, showing no significant differences in the evaluated parameters. The present study demonstrates that no modification of RNFL and macular thickness parameters is found after 1 year of treatment with VPA and CBZ monotherapy.

References

Jan 8, 1999·Pediatric Neurology·A VerrottiF Chiarelli
Jul 3, 2002·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Yasar OzkulSenay Bozlar
Jan 14, 2003·Archives of Ophthalmology·David S GreenfieldRobert W Knighton
Feb 14, 2004·American Journal of Ophthalmology·Kouros Nouri-MahdaviJoseph Caprioli
May 8, 2004·Seizure : the Journal of the British Epilepsy Association·Emma J Roff HiltonTim Betts
Jul 28, 2004·Seizure : the Journal of the British Epilepsy Association·A VerrottiF Chiarelli

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Citations

May 7, 2010·CNS Drugs·Sami Richa, Jean-Claude Yazbek
Jan 23, 2016·Seizure : the Journal of the British Epilepsy Association·Yasemin Bicer GomceliMuhammed Kazım Erol
Jan 27, 2009·Ophthalmology·Charlotte LawthomJohn M Wild
Apr 19, 2015·Journal of Neurology, Neurosurgery, and Psychiatry·Simona BalestriniSanjay M Sisodiya
Mar 31, 2009·Seizure : the Journal of the British Epilepsy Association·Zeynep AktaşAyse Serdaroglu
Oct 28, 2019·European Journal of Ophthalmology·Neslihan Bayraktar BilenDefne Kalayci
Aug 23, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Martine Clémence-FauThomas Schwitzer
Dec 8, 2007·Journal of Pediatric Ophthalmology and Strabismus·Daniel J Salchow, Kelly A Hutcheson

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