Retinal nerve fiber layer reflectometry must consider directional reflectance

Biomedical Optics Express
Xiangrun HuangJianzhong Qiao

Abstract

Recent studies reveal that measurements of retinal nerve fiber layer (RNFL) reflectance provide more sensitive detection of glaucomatous damage than RNFL thickness, but most do not consider directional reflectance of the RNFL, an important source of variability. This study quantitatively compared RNFL directional reflectance, represented by an angular spread function (ASF), measured at different scattering angles, different wavelengths and different distances from the optic nerve head (ONH) and for bundles with different thicknesses (T). An ASF was characterized by its amplitude (A) and width (W). Internal reflectance of a bundle was expressed as A/T. The study found that A varied significantly with scattering angle and wavelength and that A/T was different among bundles but constant along the same bundle, indicating that the internal structure of axons may vary among bundles but does not change with distance. This study also found that W was larger near the ONH and at longer wavelengths, but did not depend on scattering angle or T. Because a 4.3° change in incident angle can change reflected intensity by a factor of 2.7, accounting for directional reflectance should improve the accuracy and reproducibility of RNFL reflectance ...Continue Reading

References

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Citations

Mar 31, 2018·Ophthalmic & Physiological Optics : the Journal of the British College of Ophthalmic Opticians (Optometrists)·Bright S AshimateyWilliam H Swanson
Mar 22, 2018·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Bright S AshimateyWilliam H Swanson
Jul 20, 2018·Investigative Ophthalmology & Visual Science·Nitish MehtaYasha Modi
Jan 4, 2018·Biomedical Optics Express·Andreas WartakChristoph K Hitzenberger
May 16, 2019·Biomedical Optics Express·Barbara SwiatczakFrank Schaeffel
Aug 29, 2020·Translational Vision Science & Technology·Sara RisseeuwJeannette Ossewaarde-van Norel
May 27, 2021·Translational Vision Science & Technology·Riccardo CheloniJonathan Denniss

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