Retinal nerve fiber layer thickness variability in Leber hereditary optic neuropathy carriers

European Journal of Ophthalmology
Piero BarboniAlfredo A Sadun

Abstract

Recent investigations suggested that unaffected carriers of Leber hereditary optic neuropathy (LHON) may show subclinical visual alterations. Structural changes have also been detected by optical coherence tomography (OCT), which revealed a temporal thickening of the retinal nerve fiber layer (RNFL). These changes may reflect compensatory effects such as mitochondria accumulation within the RNFL axons. This study aimed to investigate whether the RNFL of LHON carriers shows greater than expected thickness variations, which may reflect transient subclinical changes, over the course of years. Using Stratus OCT, the RNFL thickness was measured yearly from 2005 to 2008 in 24 Brazilian LHON carriers, all with homoplasmic 11778/ND4 mtDNA mutation. An Italian sample of 20 healthy subjects served as a control. Data were compared also to a previously published sample (n=59) of glaucomatous eyes. The LHON carriers showed test-retest standard deviations that were larger than normal controls in the temporal (p=0.004), superior (p<0.0001), and inferior quadrants (p=0.019). Compared to the glaucoma cases, no statistical differences were observed. The RNFL thickness in LHON carriers, when measured at different time points, has higher variab...Continue Reading

References

Nov 1, 1996·American Journal of Ophthalmology·I IrakR N Weinreb
Feb 10, 2004·Progress in Retinal and Eye Research·Valerio CarelliAlfredo A Sadun
Jun 28, 2005·Investigative Ophthalmology & Visual Science·Donald L BudenzJames M Tielsch
Nov 24, 2006·Investigative Ophthalmology & Visual Science·Piero BarboniValerio Carelli
Jan 11, 2007·Ophthalmology·Donald L BudenzJames Tielsch
Aug 23, 2008·Investigative Ophthalmology & Visual Science·Nishani AmerasingheTien Yin Wong
Dec 23, 2008·Investigative Ophthalmology & Visual Science·Carolina do V F RamosPiero Barboni
Mar 10, 2009·Biochimica Et Biophysica Acta·Valerio CarelliAlfredo A Sadun

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Citations

May 24, 2018·Clinical & Experimental Ophthalmology·Nicole BalducciPiero Barboni
Feb 4, 2014·Journal of Neurology·Carlos E Mendoza-SantiestebanHoracio Kaufmann
Oct 16, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Ann L Webber
May 18, 2013·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Alfredo A Sadun
Nov 17, 2016·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Mario L R Monteiro
Aug 19, 2014·Frontiers in Neurology·Chiara La MorgiaValerio Carelli
Oct 11, 2017·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Valerio CarelliPiero Barboni
Sep 28, 2015·Human Molecular Genetics·Annalinda PisanoCarla Giordano
Apr 18, 2015·BMC Ophthalmology·Ayako MizoguchiSusumu Ishida
Oct 4, 2016·Acta Neuropathologica·Patrick Yu-Wai-ManValerio Carelli
Mar 1, 2020·Current Eye Research·Xiujuan ZhaoHui Yang

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Software Mentioned

SPSS
Stratus OCT

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